Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 866085..867366 | Replicon | chromosome |
| Accession | NZ_CP068801 | ||
| Organism | Escherichia coli strain RIVM_C018220 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | - |
| Locus tag | JNN52_RS04110 | Protein ID | WP_021528665.1 |
| Coordinates | 866085..866978 (-) | Length | 298 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | S1P7P2 |
| Locus tag | JNN52_RS04115 | Protein ID | WP_000208382.1 |
| Coordinates | 866971..867366 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JNN52_RS04090 | 861235..862218 | - | 984 | WP_001296394.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
| JNN52_RS04095 | 862844..863599 | - | 756 | Protein_803 | IS21-like element ISEc10 family helper ATPase IstB | - |
| JNN52_RS04100 | 863596..865095 | - | 1500 | WP_202847413.1 | IS21 family transposase | - |
| JNN52_RS04105 | 865444..865614 | - | 171 | Protein_805 | IS110 family transposase | - |
| JNN52_RS04110 | 866085..866978 | - | 894 | WP_021528665.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JNN52_RS04115 | 866971..867366 | - | 396 | WP_000208382.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| JNN52_RS04120 | 867435..868280 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| JNN52_RS04125 | 868365..868562 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| JNN52_RS04130 | 868579..869067 | - | 489 | WP_000761699.1 | hypothetical protein | - |
| JNN52_RS04135 | 869064..869441 | - | 378 | WP_000854690.1 | TA system toxin CbtA family protein | - |
| JNN52_RS04140 | 869530..869898 | - | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| JNN52_RS04145 | 869948..870592 | - | 645 | WP_000094916.1 | hypothetical protein | - |
| JNN52_RS04150 | 870611..870832 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| JNN52_RS04155 | 870895..871371 | - | 477 | WP_001186726.1 | RadC family protein | - |
| JNN52_RS04160 | 871387..871872 | - | 486 | WP_000849565.1 | antirestriction protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 298 a.a. Molecular weight: 34268.37 Da Isoelectric Point: 5.9850
>T187860 WP_021528665.1 NZ_CP068801:c866978-866085 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
Download Length: 894 bp
>T187860 NZ_CP090067:c45298-44978 [Acinetobacter sp. SH20PTE14]
ATGTTATTCATTGAAACCAGTATCTTTACCAAGCAAATCAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAACA
AGATCTATTGGTTCAGCCAGATAAAGGTGACTTAATCAAGAATGGCGGTGGCATTCGAAAAGTACGTTGTGCTCAAGGTA
ATAAAGGCAAAAGTGGCGGTATCAGAGTAATTTACTATTGGGTAAATGAGGATGATCAAATCTTTTTCTTGGTGGCTTAT
CCAAAATCTGTAAAAGATAATCTAACGGATAAAGAAACCGCCATTCTGCGCCAACTCGTGAAGGAGCAATTTCATGGATA
A
ATGTTATTCATTGAAACCAGTATCTTTACCAAGCAAATCAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAACA
AGATCTATTGGTTCAGCCAGATAAAGGTGACTTAATCAAGAATGGCGGTGGCATTCGAAAAGTACGTTGTGCTCAAGGTA
ATAAAGGCAAAAGTGGCGGTATCAGAGTAATTTACTATTGGGTAAATGAGGATGATCAAATCTTTTTCTTGGTGGCTTAT
CCAAAATCTGTAAAAGATAATCTAACGGATAAAGAAACCGCCATTCTGCGCCAACTCGTGAAGGAGCAATTTCATGGATA
A
Antitoxin
Download Length: 132 a.a. Molecular weight: 14640.09 Da Isoelectric Point: 11.3150
>AT187860 WP_000208382.1 NZ_CP068801:c867366-866971 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRMLIVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRMLIVGKSKINA
Download Length: 396 bp
>AT187860 NZ_CP090067:c44985-44713 [Acinetobacter sp. SH20PTE14]
ATGGATAACAACTTATTTGATGACTTAGTTGCTTCGATTAAAGAAGCAGGAGCAATCAAGCGCAAAGAGATCCAAGCTAG
TCGAACGACCGAACTTGAATTACCAGATATTAAGGAAGTGCGAGAAAAAACTGGTTTAAGTCAAAGCGAATTTGCAGCAC
GTCTCCACATTAGCCATCGTACTCTGCAAAACTGGGAACAAGGCCGACGCTATCCAACAGGACCAGCAGCAACATTGATT
CGAATTTTAGATGCACATCCTAGTCTTATTTAA
ATGGATAACAACTTATTTGATGACTTAGTTGCTTCGATTAAAGAAGCAGGAGCAATCAAGCGCAAAGAGATCCAAGCTAG
TCGAACGACCGAACTTGAATTACCAGATATTAAGGAAGTGCGAGAAAAAACTGGTTTAAGTCAAAGCGAATTTGCAGCAC
GTCTCCACATTAGCCATCGTACTCTGCAAAACTGGGAACAAGGCCGACGCTATCCAACAGGACCAGCAGCAACATTGATT
CGAATTTTAGATGCACATCCTAGTCTTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|