187854

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4578577..4579172 Replicon chromosome
Accession NZ_CP068800
Organism Escherichia coli strain RIVM_C017997

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag JNN45_RS21940 Protein ID WP_019842229.1
Coordinates 4578577..4578927 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JNN45_RS21945 Protein ID WP_001223213.1
Coordinates 4578921..4579172 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN45_RS21920 4573907..4574929 - 1023 WP_001550507.1 ABC transporter permease -
JNN45_RS21925 4574943..4576445 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
JNN45_RS21930 4576577..4577533 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JNN45_RS21935 4577843..4578373 + 531 WP_000055075.1 inorganic diphosphatase -
JNN45_RS21940 4578577..4578927 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
JNN45_RS21945 4578921..4579172 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JNN45_RS21950 4579384..4579725 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
JNN45_RS21955 4579728..4583507 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T187854 WP_019842229.1 NZ_CP068800:c4578927-4578577 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T187854 NZ_CP090065:c1328951-1328748 [Pectobacterium polonicum]
ATGAAAAAAATCGATTATTTGATGCGTTTGCGTAAATGCACAACCATAGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAGCTGGAGATGTTCTTTTCTGCAGCCGATCATCGCCTGGCAGAGCTGACAATGAACAAAC
TCTACGACAAAGTTCCGACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT187854 WP_001223213.1 NZ_CP068800:c4579172-4578921 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT187854 NZ_CP090065:c1329373-1329005 [Pectobacterium polonicum]
ATGGATGAGTACACACCAAAAAATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGATGAAAGCATAGC
AACGTTAGGCGATAGCAGTCATGGCTGGGTCAATGATCCAACCTCTGCGATCAATCTCCAATTAAATGAGCTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGATGCTGAACTACGGCGCTGGCAGAAGTCTAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References