Detailed information of TA system TA187852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4459765..4460585
• Replicon: chromosome
• Accession: NZ_CP068800
• Organism: Escherichia coli strain RIVM_C017997

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN45_RS21340
• Protein ID: WP_001550554.1
• Coordinates: 4459765..4460022 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN45_RS21345
• Protein ID: WP_001519303.1
• Coordinates: 4460034..4460585 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN45_RS21320	4455051..4456157	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN45_RS21325	4456222..4457202	+	981	WP_001519307.1	transposase	-
JNN45_RS21330	4457785..4459026	-	1242	Protein_4177	helicase YjhR	-
JNN45_RS21335	4459089..4459388	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN45_RS21340	4459765..4460022	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN45_RS21345	4460034..4460585	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN45_RS21350	4460637..4460798	+	162	WP_001519302.1	hypothetical protein	-
JNN45_RS21355	4460835..4461383	+	549	WP_001519301.1	hypothetical protein	-
JNN45_RS21360	4461510..4461770	+	261	WP_000084876.1	hypothetical protein	-
JNN45_RS21365	4461808..4461924	+	117	Protein_4184	VOC family protein	-
JNN45_RS21370	4462169..4463290	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN45_RS21375	4463287..4463565	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN45_RS21380	4463577..4464890	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE / fimB	4451175..4460798	9623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T187852 WP_001550554.1 NZ_CP068800:4459765-4460022 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T187852 NZ_CP090065:c885638-885354 [Pectobacterium polonicum]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCGCCCGTGCGGGAGCAGTTCAC
AAAAAAACTGAAAGAGGTTTTACAAAATCCCCACGTTCCCGCCAACCGACTTCATGGAATGGCTGATTGCTACAAAATCA
AACTTCGTTCCGTTGGCTATCGGCTAGTGTATCAAGTGCTTGAACATGAGATCGTAGTACTGGTTTTAGCTGTGGGCAAA
CGGGAACGCTCAGAGGTTTATAAAGCAGCCAAAGACCAACTATAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT187852 WP_001519303.1 NZ_CP068800:4460034-4460585 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT187852 NZ_CP090065:c885879-885628 [Pectobacterium polonicum]
ATGTCCGTACAACCTATCCTTGCCAATGCAGCCGTGAGTATCAGCGACTTTAAAAAGTCCCCTAATGCCGCGCTTAAAGA
AGCTAACGGCGAGCCTGTAGCCGTGCTAACCAACGGCCGTATCTCTGGCTACTATGTTTCTCCTGAAACATGGGAAGCGC
TGGCCGATTATCAGGAAGATATCGAACTTGCCAAAATCGCCCGTTCCCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8