Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 904298..905096 Replicon chromosome
Accession NZ_CP068800
Organism Escherichia coli strain RIVM_C017997

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag JNN45_RS04325 Protein ID WP_000854735.1
Coordinates 904298..904675 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag JNN45_RS04330 Protein ID WP_001285415.1
Coordinates 904722..905096 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN45_RS04295 900266..901531 - 1266 WP_001218869.1 integrase arm-type DNA-binding domain-containing protein -
JNN45_RS04300 901995..902321 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
JNN45_RS04305 902318..902581 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
JNN45_RS04310 902653..903519 - 867 WP_001280433.1 DUF4942 domain-containing protein -
JNN45_RS04315 903604..903801 - 198 WP_000839291.1 DUF957 domain-containing protein -
JNN45_RS04320 903813..904301 - 489 WP_000761676.1 hypothetical protein -
JNN45_RS04325 904298..904675 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
JNN45_RS04330 904722..905096 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN45_RS04335 905176..905397 - 222 WP_000692309.1 DUF987 domain-containing protein -
JNN45_RS04340 905460..905936 - 477 WP_001366855.1 RadC family protein -
JNN45_RS04345 905952..906431 - 480 WP_000844100.1 antirestriction protein -
JNN45_RS04350 906513..907331 - 819 WP_001234629.1 DUF945 domain-containing protein -
JNN45_RS04355 907430..907663 - 234 WP_001278287.1 DUF905 family protein -
JNN45_RS04360 907669..908346 - 678 WP_042104028.1 hypothetical protein -
JNN45_RS04365 908494..909174 - 681 WP_001593697.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / papX 788604..938673 150069


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T187832 WP_000854735.1 NZ_CP068800:c904675-904298 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T187832 NZ_CP090061:c2672626-2672093 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT187832 WP_001285415.1 NZ_CP068800:c905096-904722 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT187832 NZ_CP090061:c2672903-2672637 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References