Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 829643..830478 Replicon chromosome
Accession NZ_CP068800
Organism Escherichia coli strain RIVM_C017997

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag JNN45_RS03920 Protein ID WP_001564063.1
Coordinates 829643..830020 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag JNN45_RS03925 Protein ID WP_021553056.1
Coordinates 830110..830478 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN45_RS03890 824771..825919 - 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -
JNN45_RS03895 825991..826974 - 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -
JNN45_RS03900 827784..827954 - 171 Protein_765 IS110 family transposase -
JNN45_RS03905 828297..829139 - 843 Protein_766 DUF4942 domain-containing protein -
JNN45_RS03910 829224..829418 - 195 WP_024181941.1 DUF957 domain-containing protein -
JNN45_RS03915 829497..829646 - 150 Protein_768 hypothetical protein -
JNN45_RS03920 829643..830020 - 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
JNN45_RS03925 830110..830478 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN45_RS03930 830641..830862 - 222 WP_000692345.1 DUF987 domain-containing protein -
JNN45_RS03935 830927..831403 - 477 WP_021553055.1 RadC family protein -
JNN45_RS03940 831419..831898 - 480 WP_001564060.1 antirestriction protein -
JNN45_RS03945 832164..832982 - 819 WP_001564059.1 DUF945 domain-containing protein -
JNN45_RS03950 833072..833305 - 234 WP_001278293.1 DUF905 family protein -
JNN45_RS03955 833311..833988 - 678 WP_001564058.1 hypothetical protein -
JNN45_RS03960 834139..834819 - 681 WP_001278649.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / papX 788604..938673 150069


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T187831 WP_001564063.1 NZ_CP068800:c830020-829643 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T187831 NZ_CP090061:2059804-2060022 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT187831 WP_021553056.1 NZ_CP068800:c830478-830110 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT187831 NZ_CP090061:2059403-2059777 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References