Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 161180..161792 | Replicon | chromosome |
| Accession | NZ_CP068800 | ||
| Organism | Escherichia coli strain RIVM_C017997 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | U9YXE2 |
| Locus tag | JNN45_RS00685 | Protein ID | WP_000833473.1 |
| Coordinates | 161180..161365 (+) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | L4IWR9 |
| Locus tag | JNN45_RS00690 | Protein ID | WP_000499744.1 |
| Coordinates | 161382..161792 (+) | Length | 137 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JNN45_RS00675 | 158021..159172 | + | 1152 | WP_000741501.1 | L-threonine dehydrogenase | - |
| JNN45_RS00680 | 159373..160911 | + | 1539 | WP_001551836.1 | aldehyde dehydrogenase AldB | - |
| JNN45_RS00685 | 161180..161365 | + | 186 | WP_000833473.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| JNN45_RS00690 | 161382..161792 | + | 411 | WP_000499744.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| JNN45_RS00695 | 161864..163828 | - | 1965 | WP_001551835.1 | glycoside hydrolase family 127 protein | - |
| JNN45_RS00700 | 163839..165239 | - | 1401 | WP_000204811.1 | MFS transporter | - |
| JNN45_RS00705 | 165465..166280 | + | 816 | WP_000891823.1 | AraC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6800.89 Da Isoelectric Point: 11.7053
>T187828 WP_000833473.1 NZ_CP068800:161180-161365 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF
Download Length: 186 bp
>T187828 NZ_CP090059:c3789535-3788651 [Sphingomonas cannabina]
ATGGCTAAGGAGATCAAGAATATCGGCGCCTCGGTGCGCGCCCGCCTCCTGCAGGTCGCCAAGGCAAGCGGTCAGAGCTT
TGATCTTGTCCTGACGCGCTTTGCGCTCGAACGACTCCTCTTCCGGCTCAGCCAATCACCGCATGCGGACCGCTTCGTTC
TGAAAGGTGCGATGCTGATGATGAGTTGGTTTGAGGATCCATATCGCGGCACGCGTGACCTCGATCTGTTGGGGTTTGGT
GACCCTGAACCAGAGGCGATGCTCGCGACATTTCGAGGCATCCTGGCGCTCAACGATGATGATGGTGCGGAATTTGACGT
CGATGCTCTTCGCGTCGATCGCATTCGCGAAGAGCTCGAATATGGCGGGCTGAGGCTGCGGACAACCGCCTCGATCAGCG
GCGCCAGGATCAATCTGACGATCGACATCGGCTTCGGTGATGCGATGGAACCCGGTGCGGAGATGCTCGACTATCCCTCC
ATGTTGGCGTTTCCCGCACCGCGTCTGCGTGCCTACGCGCGCGAAACTGTTATTGCTGAGAAGTTTCAGGCGATGGTCGC
GCTCGGACGCGCGAACAGTCGCATGAAGGATTTCTACGACATCTGGATCCTCAGCAAGTCGTTCGATTTCGCCGGCGACA
GGCTCGCCCGCGCGATCGCTGCAACGTTTGCCCGGCGCGAGACAGCGGTTCCTGTCGATTTGCCCGATGCACTAACGCCG
GCTTTCGCCAACGATGAACAAAAACAGCGACAGTGGAACGCCTTTGTCAGGGATGTTTCCGCTAATCCGGGAAGCTTGGA
AGATGTCGTGAACAGCTTGGCTGATTTTCTGATGCCGCACGCTATACAAGCGCGCGCTTCAAATAATAATGGTTCAAAGT
TGTAA
ATGGCTAAGGAGATCAAGAATATCGGCGCCTCGGTGCGCGCCCGCCTCCTGCAGGTCGCCAAGGCAAGCGGTCAGAGCTT
TGATCTTGTCCTGACGCGCTTTGCGCTCGAACGACTCCTCTTCCGGCTCAGCCAATCACCGCATGCGGACCGCTTCGTTC
TGAAAGGTGCGATGCTGATGATGAGTTGGTTTGAGGATCCATATCGCGGCACGCGTGACCTCGATCTGTTGGGGTTTGGT
GACCCTGAACCAGAGGCGATGCTCGCGACATTTCGAGGCATCCTGGCGCTCAACGATGATGATGGTGCGGAATTTGACGT
CGATGCTCTTCGCGTCGATCGCATTCGCGAAGAGCTCGAATATGGCGGGCTGAGGCTGCGGACAACCGCCTCGATCAGCG
GCGCCAGGATCAATCTGACGATCGACATCGGCTTCGGTGATGCGATGGAACCCGGTGCGGAGATGCTCGACTATCCCTCC
ATGTTGGCGTTTCCCGCACCGCGTCTGCGTGCCTACGCGCGCGAAACTGTTATTGCTGAGAAGTTTCAGGCGATGGTCGC
GCTCGGACGCGCGAACAGTCGCATGAAGGATTTCTACGACATCTGGATCCTCAGCAAGTCGTTCGATTTCGCCGGCGACA
GGCTCGCCCGCGCGATCGCTGCAACGTTTGCCCGGCGCGAGACAGCGGTTCCTGTCGATTTGCCCGATGCACTAACGCCG
GCTTTCGCCAACGATGAACAAAAACAGCGACAGTGGAACGCCTTTGTCAGGGATGTTTCCGCTAATCCGGGAAGCTTGGA
AGATGTCGTGAACAGCTTGGCTGATTTTCTGATGCCGCACGCTATACAAGCGCGCGCTTCAAATAATAATGGTTCAAAGT
TGTAA
Antitoxin
Download Length: 137 a.a. Molecular weight: 15241.15 Da Isoelectric Point: 4.5486
>AT187828 WP_000499744.1 NZ_CP068800:161382-161792 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV
Download Length: 411 bp
>AT187828 NZ_CP090059:c3790145-3789528 [Sphingomonas cannabina]
ATGCCCGAAACCGCGTCCCAGCGCCACATTGCTCACTCCGTGCTGAAAGCGCGCGGTATTGCGCGTCTTGCCGAGCTGCG
GACCGCGGGAGTGACCGCGGCAACTATGAGCCGCATGGAGCGGGATGGCGAGGTGCTCCGACTTGCGCGAGGGCTTTACC
AACTCCCTGATGCGCCGCTCGACGCGCATCACAGTCTAGCCGAGGCAGCGAAACGGGTGCCTAAGGGTGTGGTCTGTCTC
GTCTCGGCCCTCGCGTTCCATCAACTTACCGATCAGCTCCCAAGGCAGGTGTGGATCGCCATCGGCCAAAAGGATTGGGC
TCCCAAGGGTGATGGGGCGCCAGTTCGGCTCGTGCGCTTCACGGATCGCCTCCTTACGGAAGGTGTCGAATCCCACACCG
TCGAAGGGGTGCCCGTAAAGATTTTTGGGGTCGCCAAGACGGTCGCCGACTGCTTCCGGTATCGCAACAAGATCGGCCTG
TCGGTGGCGATCGAGGGCCTCCAGGAGGCGCTGCGTCAACGCAAGACAACCCCTGGCGAAATCGTCAGGCAAGCCGAGCG
AGGAGCGATCGCGACGGTCATTCGACCCTATCTCGAGGCGCTGACCGCCAATGGCTAA
ATGCCCGAAACCGCGTCCCAGCGCCACATTGCTCACTCCGTGCTGAAAGCGCGCGGTATTGCGCGTCTTGCCGAGCTGCG
GACCGCGGGAGTGACCGCGGCAACTATGAGCCGCATGGAGCGGGATGGCGAGGTGCTCCGACTTGCGCGAGGGCTTTACC
AACTCCCTGATGCGCCGCTCGACGCGCATCACAGTCTAGCCGAGGCAGCGAAACGGGTGCCTAAGGGTGTGGTCTGTCTC
GTCTCGGCCCTCGCGTTCCATCAACTTACCGATCAGCTCCCAAGGCAGGTGTGGATCGCCATCGGCCAAAAGGATTGGGC
TCCCAAGGGTGATGGGGCGCCAGTTCGGCTCGTGCGCTTCACGGATCGCCTCCTTACGGAAGGTGTCGAATCCCACACCG
TCGAAGGGGTGCCCGTAAAGATTTTTGGGGTCGCCAAGACGGTCGCCGACTGCTTCCGGTATCGCAACAAGATCGGCCTG
TCGGTGGCGATCGAGGGCCTCCAGGAGGCGCTGCGTCAACGCAAGACAACCCCTGGCGAAATCGTCAGGCAAGCCGAGCG
AGGAGCGATCGCGACGGTCATTCGACCCTATCTCGAGGCGCTGACCGCCAATGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|