Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4442810..4443645 Replicon chromosome
Accession NZ_CP068799
Organism Escherichia coli strain RIVM_C017887

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag JNN46_RS21360 Protein ID WP_001094426.1
Coordinates 4442810..4443187 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag JNN46_RS21365 Protein ID WP_001285575.1
Coordinates 4443277..4443645 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN46_RS21335 4438313..4438492 + 180 WP_001298063.1 hypothetical protein -
JNN46_RS21340 4438891..4440927 - 2037 WP_000417001.1 hypothetical protein -
JNN46_RS21345 4441879..4442037 - 159 WP_001467148.1 hypothetical protein -
JNN46_RS21350 4442116..4442313 - 198 WP_000839272.1 DUF957 domain-containing protein -
JNN46_RS21355 4442325..4442813 - 489 WP_000761683.1 hypothetical protein -
JNN46_RS21360 4442810..4443187 - 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
JNN46_RS21365 4443277..4443645 - 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN46_RS21370 4443725..4443946 - 222 WP_000692350.1 DUF987 domain-containing protein -
JNN46_RS21375 4444033..4444509 - 477 WP_001298074.1 RadC family protein -
JNN46_RS21380 4444524..4445009 - 486 WP_000213697.1 antirestriction protein -
JNN46_RS21385 4445100..4445918 - 819 WP_001175160.1 DUF945 domain-containing protein -
JNN46_RS21390 4446008..4446241 - 234 WP_001278290.1 DUF905 family protein -
JNN46_RS21395 4446247..4446924 - 678 WP_001097301.1 hypothetical protein -
JNN46_RS21400 4447072..4447752 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4432230..4459478 27248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T187825 WP_001094426.1 NZ_CP068799:c4443187-4442810 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T187825 NZ_CP090059:713209-714072 [Sphingomonas cannabina]
ATGGCTAGTGAACGGGCCAACCGGGCGGCATCGGTCAAGGATCGTCTGCTCAACCTCGCCAGGCGCGACGGCCGCGTCTT
CGACGTCGTGCTCGTCCGCTACGCATTGGAGCGCCTGCTCTACCGGCTCTCGCTCTCGAAGCACCGCGACCGCTTCGTGC
TGAAGGGCGGCATGCTGGTCACGATCTGGCTGCCCGGGGGCAACCGCGAAACCCGCGACGCCGATTTCCTCGGCTACGGC
GATGCCAGTGAAGCGACGATCCGCGCGACCTTCGCCGAGATCATGGCGATCGCAAGCGATGACGGCCTGCGCTTCGACAT
CGACAACATGACCGTCGCAACCATTCGCGACGACATCGAATATGGCGGCATCCGCCTGCGCGTGTCGGCCTATCTTGAGC
GCACCCGGATTCCGATGGTGGTCGACATCGGCTTTGGCGACGCGCTTCCGACGCCGCCCGGTGAACTGGACTATCCGACC
CTGCTCGACATGGAGGTGCCGCGGATTCGTTCCTATCCGCCGGTCACCGTCATTGCCGAGAAATTCCAGGCAATGGTCCA
GCTCGGCATCGGCAATGGCCGGATGAAGGACTACTACGATCTCTGGGCGCTGCCGCAGGCCATGCCCATCGCGGCGGACG
AACTGGATGCAGCGATCCGGGCGACATTCGAGCGGCGCGGGACCGACATACCGCGCGAGCGGCCGCCCGGCCTGTCCCCC
GAGCTGGCCGACGACGAGACCAAGCAGCGCCAGTGGCGCGCCTATGCCGCCTCGATCGAGCTCGAAGGCGTGTCGTTGGC
TGAGGTCGTCGAGGCCATCTGGGCTTTGGTCGGCCCCTCCTGCCAGCGACTGGCGGGAAGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT187825 WP_001285575.1 NZ_CP068799:c4443645-4443277 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT187825 NZ_CP090059:712596-713216 [Sphingomonas cannabina]
ATGGCGCCCGTGCCAGAGACCCAGCGCGACCGGCTGCGTGACCTGCTCGTCCAGCACCCCGTCGCGCGTGCGCAGGAGCT
GCGCAATGCCGGCATCGCCGCTGCGACGATCGCGCGCGCCGTGAAGGACGGCGAGGTCGAGCGCGTCGGCCGTGGCCTCT
ACCAGCGTCCGGACGCAGCGATCGATGCGGCGCACGCGCTTGCCGAAACCGCGAAGCGAATCCCCAAGGGAGTGATCGCA
ATGGTCTCGGCGCTCGCTTTCCACGGGCTCACCGACCAGATGCCGCGCAAGGTCTGGGTGGCGATCGGGCCGGGCGACTG
GTCGCCCGTCTCTTCCTATCCACCGACCCGGATTGTCCGTTTCAGCGAGAAATACCTCCGCGAGGGAGTCGAGCACCACA
TGATCTCGGGCGTCAGCGTTCCGATCTACTCGATCCCCAAGACGCTCGCCGACCTGTTCCGCAATTCCAAGCTGGTCGAT
CGCTCGGTGGCGGTCGAAGGGCTGCGTGCGGCGCTCGACCAGCGCAAGGCCACGCCGGCCGCGATCGCACAGGCGGCAAA
GGCCGGCGGCGCCTGGCGCATCATGCGGCCCTATCTCGAGGCGCTCACTTTCAATGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References