Detailed information of TA system TA187812

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3206970..3207814
• Replicon: chromosome
• Accession: NZ_CP068799
• Organism: Escherichia coli strain RIVM_C017887

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: JNN46_RS15365
• Protein ID: WP_000854686.1
• Coordinates: 3206970..3207353 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: JNN46_RS15370
• Protein ID: WP_001285602.1
• Coordinates: 3207434..3207814 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN46_RS15335	3203646..3204350	+	705	WP_001241673.1	leucyl/phenylalanyl-tRNA--protein transferase	-
JNN46_RS15340	3204635..3204853	+	219	WP_001040187.1	translation initiation factor IF-1	-
JNN46_RS15350	3205344..3206186	-	843	WP_001431817.1	DUF4942 domain-containing protein	-
JNN46_RS15355	3206271..3206468	-	198	WP_000839253.1	DUF957 domain-containing protein	-
JNN46_RS15360	3206485..3206973	-	489	WP_001054233.1	hypothetical protein	-
JNN46_RS15365	3206970..3207353	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
JNN46_RS15370	3207434..3207814	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JNN46_RS15375	3207825..3208508	-	684	WP_000086768.1	hypothetical protein	-
JNN46_RS15380	3208527..3208748	-	222	WP_000692298.1	DUF987 domain-containing protein	-
JNN46_RS15385	3208811..3209287	-	477	WP_001186726.1	RadC family protein	-
JNN46_RS15390	3209303..3209788	-	486	WP_000214307.1	antirestriction protein	-
JNN46_RS15395	3209880..3210698	-	819	WP_001234732.1	DUF945 domain-containing protein	-
JNN46_RS15400	3210798..3211031	-	234	WP_001119719.1	DUF905 family protein	-
JNN46_RS15405	3211110..3211565	-	456	WP_001504120.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T187812 WP_000854686.1 NZ_CP068799:c3207353-3206970 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T187812 NZ_CP090028:c301092-300781 [Serratia ureilytica]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGGGGTGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAGTACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCGTCATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT187812 WP_001285602.1 NZ_CP068799:c3207814-3207434 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT187812 NZ_CP090028:c300784-300362 [Serratia ureilytica]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTACCCTTATTGCAGGGCAGCCACGCTCAGCAAGA
CTACCGAGACGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACGCCATCCGCTGATTGACATGTTGGCAAAAA
AAATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAGGGGGTGGCC
GCGCTTCGCGTATTGATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGCAAAAAGTCGTTGGTTAA
CCAAATCCTGAACGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCCCCAGCCC
TGTTCCTGCCGGAAGCGGATTAA