Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1995054..1995885 | Replicon | chromosome |
| Accession | NZ_CP068799 | ||
| Organism | Escherichia coli strain RIVM_C017887 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1P968 |
| Locus tag | JNN46_RS09410 | Protein ID | WP_000854814.1 |
| Coordinates | 1995054..1995428 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | JNN46_RS09415 | Protein ID | WP_024174331.1 |
| Coordinates | 1995517..1995885 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JNN46_RS09370 | 1990450..1991616 | + | 1167 | WP_001297905.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| JNN46_RS09375 | 1991735..1992208 | + | 474 | WP_001105376.1 | DNA gyrase inhibitor SbmC | - |
| JNN46_RS09380 | 1992406..1993464 | + | 1059 | WP_001200890.1 | FUSC family protein | - |
| JNN46_RS09385 | 1993636..1993965 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| JNN46_RS09390 | 1994066..1994248 | - | 183 | WP_001016348.1 | hypothetical protein | - |
| JNN46_RS09395 | 1994302..1994448 | + | 147 | Protein_1839 | transposase domain-containing protein | - |
| JNN46_RS09400 | 1994737..1994850 | - | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| JNN46_RS09405 | 1994863..1995057 | - | 195 | WP_000988601.1 | hypothetical protein | - |
| JNN46_RS09410 | 1995054..1995428 | - | 375 | WP_000854814.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| JNN46_RS09415 | 1995517..1995885 | - | 369 | WP_024174331.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JNN46_RS09420 | 1995959..1996180 | - | 222 | WP_000692346.1 | DUF987 domain-containing protein | - |
| JNN46_RS09425 | 1996249..1996725 | - | 477 | WP_001541535.1 | RadC family protein | - |
| JNN46_RS09430 | 1996741..1997214 | - | 474 | WP_000855074.1 | antirestriction protein | - |
| JNN46_RS09435 | 1997477..1998298 | - | 822 | WP_001234571.1 | DUF945 domain-containing protein | - |
| JNN46_RS09440 | 1998519..1998929 | - | 411 | WP_000846704.1 | hypothetical protein | - |
| JNN46_RS09445 | 1998945..1999622 | - | 678 | WP_001362823.1 | hypothetical protein | - |
| JNN46_RS09450 | 1999758..2000828 | - | 1071 | WP_000102631.1 | patatin-like phospholipase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T187801 WP_000854814.1 NZ_CP068799:c1995428-1995054 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T187801 NZ_CP090005:2359455-2359913 [Providencia rettgeri]
ATGATTTTGTATCGATTGGTTAAATCCAGTTTTATTCACGATGCATGGTCTGGTCAAGGAGCCATGCTCTACGGTGGGCG
TTGGAATCATAAAGGAACTCCCGCTGTTTATACTTCAACCAGTATTTCATTAGCCACCCTTGAAATACTCGTTCACATCA
ATCAAGACTTACTATTAAACCAGTTCAGTTTGCTATCCATCGATATCAATGACAGGTACGTGATGAAATTATCGTTAGAC
CACCTTCCAACAGATTGGCAGCAAGACCCAGCGCCAACTTCTACCATGGATATTGGTACTACATGGCTAAATAACCAAGA
TAGCTTAGTATTATTAATTCCCTCTTGTATTATTCCCTACGAATACAATGCAATTATTAACCCGTTGCACCCGCAATTTC
AAAAAGCCATACATACCGTTAAACCGCTGGATTTTAGTGTTGACCCACGCTTAGCATAG
ATGATTTTGTATCGATTGGTTAAATCCAGTTTTATTCACGATGCATGGTCTGGTCAAGGAGCCATGCTCTACGGTGGGCG
TTGGAATCATAAAGGAACTCCCGCTGTTTATACTTCAACCAGTATTTCATTAGCCACCCTTGAAATACTCGTTCACATCA
ATCAAGACTTACTATTAAACCAGTTCAGTTTGCTATCCATCGATATCAATGACAGGTACGTGATGAAATTATCGTTAGAC
CACCTTCCAACAGATTGGCAGCAAGACCCAGCGCCAACTTCTACCATGGATATTGGTACTACATGGCTAAATAACCAAGA
TAGCTTAGTATTATTAATTCCCTCTTGTATTATTCCCTACGAATACAATGCAATTATTAACCCGTTGCACCCGCAATTTC
AAAAAGCCATACATACCGTTAAACCGCTGGATTTTAGTGTTGACCCACGCTTAGCATAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13603.42 Da Isoelectric Point: 6.7386
>AT187801 WP_024174331.1 NZ_CP068799:c1995885-1995517 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT
Download Length: 369 bp
>AT187801 NZ_CP090005:2358997-2359458 [Providencia rettgeri]
ATGAGAAACTATATCCCCACAACCCCACTTCAACCGACTGCTTCATCTTTTAAACCACTATGGCGCCATGTAGGGTTACC
TGCCGAACGTGGTATTGAATTGACCCACTTCTTACGCCAAGGGCTGTCTGTCTCTGTTTTAGACAATATCCAAGAATGGT
CAGGGATGAGTAAAACTGAATTATTACGGATATCCGGCATTAATGAACGCAATATTGCTCGTCGCAAAAATGCAGGCCAA
CCCCTCAATGCTGATGAAAGCGAACGAATTGCTCGTCTAGTACGCGTATTCGATGCGGCAGTGCGTTTATTTAATGGAGA
TAAACATGCAGCAGGTGATTGGCTTAATCACCCCGTTAAAGGGTTAGGCCATTTACGCCCTATTGAGCTTATTGCGACAG
AAAGTGGAGCCATTGAGGTAATTGATTTGATTGGCCGCATTGAGCATGGTGTGTTTTCATGA
ATGAGAAACTATATCCCCACAACCCCACTTCAACCGACTGCTTCATCTTTTAAACCACTATGGCGCCATGTAGGGTTACC
TGCCGAACGTGGTATTGAATTGACCCACTTCTTACGCCAAGGGCTGTCTGTCTCTGTTTTAGACAATATCCAAGAATGGT
CAGGGATGAGTAAAACTGAATTATTACGGATATCCGGCATTAATGAACGCAATATTGCTCGTCGCAAAAATGCAGGCCAA
CCCCTCAATGCTGATGAAAGCGAACGAATTGCTCGTCTAGTACGCGTATTCGATGCGGCAGTGCGTTTATTTAATGGAGA
TAAACATGCAGCAGGTGATTGGCTTAATCACCCCGTTAAAGGGTTAGGCCATTTACGCCCTATTGAGCTTATTGCGACAG
AAAGTGGAGCCATTGAGGTAATTGATTTGATTGGCCGCATTGAGCATGGTGTGTTTTCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|