Detailed information of TA system TA187797

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 830498..831330
• Replicon: chromosome
• Accession: NZ_CP068799
• Organism: Escherichia coli strain RIVM_C017887

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: S1PD64
• Locus tag: JNN46_RS03970
• Protein ID: WP_000854753.1
• Coordinates: 830498..830872 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: JNN46_RS03975
• Protein ID: WP_001531802.1
• Coordinates: 830962..831330 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN46_RS03940	825613..826761	-	1149	WP_000905914.1	capsule polysaccharide transporter	-
JNN46_RS03945	826833..827816	-	984	WP_001335608.1	KpsF/GutQ family sugar-phosphate isomerase	-
JNN46_RS03950	828626..828796	-	171	Protein_776	IS110 family transposase	-
JNN46_RS03955	829138..829707	-	570	WP_001290247.1	DUF4942 domain-containing protein	-
JNN46_RS03960	829804..830001	-	198	WP_000839281.1	DUF957 domain-containing protein	-
JNN46_RS03965	830013..830501	-	489	WP_000777541.1	hypothetical protein	-
JNN46_RS03970	830498..830872	-	375	WP_000854753.1	TA system toxin CbtA family protein	Toxin
JNN46_RS03975	830962..831330	-	369	WP_001531802.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JNN46_RS03980	831493..831714	-	222	WP_000692329.1	DUF987 domain-containing protein	-
JNN46_RS03985	831777..832253	-	477	WP_001186726.1	RadC family protein	-
JNN46_RS03990	832269..832754	-	486	WP_001531954.1	antirestriction protein	-
JNN46_RS03995	832809..833630	-	822	WP_202847156.1	DUF945 domain-containing protein	-
JNN46_RS04000	833711..833922	+	212	Protein_786	hypothetical protein	-
JNN46_RS04005	834041..834496	-	456	WP_000581502.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	828626..828730	104

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14005.00 Da
• Isoelectric Point: 8.2905

>T187797 WP_000854753.1 NZ_CP068799:c830872-830498 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Nucleotide

• Length: 375 bp

>T187797 NZ_CP090004:820364-820648 [Flagellimonas sp. HMM57]
ATGAAAACCTCAAAATTTGATATAGCAGATTATCTGGACAGTAAAGAAATGATTGCCGAATACTTGAACACGGTTTTGGA
GGAAGGCGATAACGCAGATATAATCAATGCCATCGGACATGTTGCTAAGGCAATAGGAATGACCAAAATATCCGAAGAAA
CTGGATTGAGCAGACCCAGTCTCTACAAAGCTTTATCGGATGGGGCCAAACCTCAATTTGCAACGGTAATAAAGGTTTTG
AAAGCTATTGGGGGGAAAATTCAAGTAAACCCTATATCTTCATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13422.27 Da
• Isoelectric Point: 6.3161

>AT187797 WP_001531802.1 NZ_CP068799:c831330-830962 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNSLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT187797 NZ_CP090004:820062-820367 [Flagellimonas sp. HMM57]
ATGTTCTTTATTGAGAAAACAATTGAATTTGACAAGTGGTTTAGAAAACTAAAAAAACTGAAAGCCAAGTCAAAAATATT
GTTCAGAATTCAAAAGATTCAAAGCAACGGACATTTTGGAGATTGTAAAGCTGTTGGTGATGGAATTCGAGAAAAAGGGG
TAAATTTTGCTAAAGGCTATCGTGTTTACTTCAAAGAGAAAAAGGGGAAAATAGTTATTTTACTTATTGGAGGAGATAAA
TCCACACAGCAAAAGGACATCTTGAAAGCAAAAGATATTTGGAAAAACTTAATAGATAAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A7U9LVU0