Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4169419..4170038 Replicon chromosome
Accession NZ_CP068798
Organism Klebsiella pneumoniae strain RIVM_C015043

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JNN64_RS20600 Protein ID WP_002892050.1
Coordinates 4169820..4170038 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JNN64_RS20595 Protein ID WP_002892066.1
Coordinates 4169419..4169793 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN64_RS20585 4164571..4165764 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JNN64_RS20590 4165787..4168933 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JNN64_RS20595 4169419..4169793 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JNN64_RS20600 4169820..4170038 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JNN64_RS20605 4170197..4170763 + 567 WP_002892030.1 maltose O-acetyltransferase -
JNN64_RS20610 4170735..4170875 - 141 WP_004147370.1 hypothetical protein -
JNN64_RS20615 4170896..4171366 + 471 WP_002892026.1 YlaC family protein -
JNN64_RS20620 4171341..4172792 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JNN64_RS20625 4172893..4173591 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
JNN64_RS20630 4173588..4173728 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JNN64_RS20635 4173728..4173991 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T187789 WP_002892050.1 NZ_CP068798:4169820-4170038 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T187789 NZ_CP090000:c4411889-4411737 [Xanthomonas translucens]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT187789 WP_002892066.1 NZ_CP068798:4169419-4169793 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT187789 NZ_CP090000:c4411638-4411504 [Xanthomonas translucens]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References