Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2766611..2768199 Replicon chromosome
Accession NZ_CP068798
Organism Klebsiella pneumoniae strain RIVM_C015043

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag JNN64_RS13665 Protein ID WP_002904792.1
Coordinates 2766611..2767933 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JNN64_RS13670 Protein ID WP_002904790.1
Coordinates 2767933..2768199 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN64_RS13650 2761667..2764168 + 2502 WP_004151634.1 fimbrial biogenesis outer membrane usher protein -
JNN64_RS13655 2764156..2765160 + 1005 WP_002904798.1 type 1 fimbrial protein -
JNN64_RS13660 2765302..2766594 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JNN64_RS13665 2766611..2767933 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
JNN64_RS13670 2767933..2768199 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JNN64_RS13675 2768465..2768791 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JNN64_RS13680 2768788..2769288 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JNN64_RS13685 2769266..2770645 - 1380 WP_002904785.1 purine permease -
JNN64_RS13690 2770991..2772145 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JNN64_RS13695 2772126..2773049 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2568383..2804749 236366


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T187787 WP_002904792.1 NZ_CP068798:c2767933-2766611 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T187787 NZ_CP090000:4116168-4117424 [Xanthomonas translucens]
ATGAAAGGAAAGATAAGTAATGCATGCAAGCCAGACATCACTCCCATTCTTGTGGATGGCTTAGCATCGACAGCAACGCA
AGGTGCCGCAGATGACTCGGCTTCCAGGCTGCCACAGCAGGCGTTGCTTGATGGTCTGCAGGAAAGGCCGCAGGCCCTTA
AAAAATCCAATTCGGCCGATTGGTCTGCTCGCACTCTCCCGCAATGGGCGCCGGGTCCAGGGACATCATCAAAAGCCCTG
CTGATCCAATCGCCTCCTCACCCCACAAGTTCAGACGAGATGTTTGGACTGGGTGAGCTTCCAGCGCCCGGAAAAGCCCG
ATGGGAATATCTTACGAAAACCGAGAACTGGCATCCAGAGCGCCAGGAATTGCATAGCCGGCTATTGAGCCAAGCACGAA
CTGCATCCCTGCGCTTGGCCGAATCAATTGAGAGCGACGGCTACCCACCAACATTGTTCGCATTACGAGGCAATACTGCC
ACTGGTAAGACGCGTATAGCGACAAAGACGATTCCTGTGCTCGCAAATGCGCTCAAGAAGAGCAGTGGCGGCGGCTGCAT
TAATCCTGACATCTTTAAACGTTCACTAGCGGAATCGCAAGGAGAAGCAATGAAACTCAGTTCGGCGCAGGTACACGCCG
AATCATGCGTCCTCGCCGATCGGCTTGAAAACGAGCTTCGCTCGCAAAGGACCACAAGCGGTGCAATGGCCAGCATACTC
GTCGACAAACGACTGGCAAACACGCATGAGGTCGACAGCTACGTCAGTTTAGCCAAGGAGACAGGGCGCAAGGTCGAGTT
GTGCGATATCGATGCGCCTCTTGAGCGATCCCTTATGGGCGTACTTCAGAGAAGTCCGGGAGGTGATGATCCACGACCGC
CTTACGTGGCGGTTGCGAATGGATTTTCGACTGTCCGGAGCAACCGCTTAGATGTCATCGACAGGTTCCTGTCAAATCCA
ACCTTGGGAAGTTATCGCCTGTTCGGCACGAATGAAAAGGGTGAAAAAGTGATGGTTGCCAGCGTCGCCGATGGCGAACT
CAGCATTCACGACCCCCAGTTGTATGAGAGCATTACAGCTCCCGAGGACTTCAACTCGGGTGACAAAGGAGAACAGGTAA
TCGACACAGCGCTGATTGACCGTTTGAGCAACAGCATCGATGATCCAAAGCGTGCAACGGATGCACGTGCCGCCCTGGAG
AAATACAAGGGAATGACGTGGTCAAATGCTCTAGCGGCACACAGCTCATTGATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT187787 WP_002904790.1 NZ_CP068798:c2768199-2767933 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT187787 NZ_CP090000:4117438-4117734 [Xanthomonas translucens]
ATGACCCACTTAAAAGGCGCAGATGCACTTGCCCTGCATAAGAAACTCAAGGAGCGCAATGCCTCATTACGCAGTGCCGA
ACTTGATTCAGCAAAGGCGCTAGCCCATGAAAGCGGCAAAGAGCGCTTCAACCTCGAAAAATTGGAGAGCATTTGCGACA
CCACTCAAGCAGGGCGCATTACCGACCCGAACGATCGTCAGGCCATTTACGAACAAATGTATTATGTCGAGCATCCCAAA
GTCAGCACCTTGCAAGAATTCGCCCGCATTGTGGTGACGATTTCCTCATGGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References