Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 796291..796948 Replicon chromosome
Accession NZ_CP068798
Organism Klebsiella pneumoniae strain RIVM_C015043

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JNN64_RS03960 Protein ID WP_002916310.1
Coordinates 796538..796948 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JNN64_RS03955 Protein ID WP_002916312.1
Coordinates 796291..796557 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN64_RS03930 791499..792932 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
JNN64_RS03935 793051..793779 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JNN64_RS03940 793829..794140 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JNN64_RS03945 794304..794963 + 660 WP_002916317.1 hemolysin III family protein -
JNN64_RS03950 795062..796045 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JNN64_RS03955 796291..796557 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JNN64_RS03960 796538..796948 + 411 WP_002916310.1 protein YgfX Toxin
JNN64_RS03965 796955..797476 - 522 WP_002916308.1 flavodoxin FldB -
JNN64_RS03970 797577..798473 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JNN64_RS03975 798496..799209 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JNN64_RS03980 799215..800948 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T187778 WP_002916310.1 NZ_CP068798:796538-796948 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T187778 NZ_CP089999:3660114-3660365 [Xanthomonas translucens]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTTGCGGACACCATGGAGCGTGTCGTCAACAATCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTGCGCAGCCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTAGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT187778 WP_002916312.1 NZ_CP068798:796291-796557 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT187778 NZ_CP089999:3660362-3660619 [Xanthomonas translucens]
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACGACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAGCGCAT
CAACGACCTGATCAAAGCCATTCAACGCGATCCCTTCCAGGGCGTCGGCAAGCCAGAACGGCTACGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACACCGCATCGTCTACAAGGTCGAGGCGGGCGTCCTACTGATCGCGCAGGTG
CGGTATCACTACGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References