Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4845547..4846063 Replicon chromosome
Accession NZ_CP068797
Organism Klebsiella pneumoniae strain RIVM_C014073

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag JNN67_RS23845 Protein ID WP_009486548.1
Coordinates 4845547..4845831 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JNN67_RS23850 Protein ID WP_002886901.1
Coordinates 4845821..4846063 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN67_RS23820 4840964..4841272 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JNN67_RS23825 4841357..4841530 + 174 WP_002886906.1 hypothetical protein -
JNN67_RS23830 4841533..4842276 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JNN67_RS23835 4842633..4844771 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JNN67_RS23840 4845079..4845543 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JNN67_RS23845 4845547..4845831 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JNN67_RS23850 4845821..4846063 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JNN67_RS23855 4846141..4848051 - 1911 WP_009486549.1 BglG family transcription antiterminator -
JNN67_RS23860 4848074..4849228 - 1155 WP_020316350.1 lactonase family protein -
JNN67_RS23865 4849295..4850035 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T187773 WP_009486548.1 NZ_CP068797:c4845831-4845547 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T187773 NZ_CP089993:4935442-4935792 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT187773 WP_002886901.1 NZ_CP068797:c4846063-4845821 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT187773 NZ_CP089993:4935150-4935437 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References