Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4084568..4085187 Replicon chromosome
Accession NZ_CP068797
Organism Klebsiella pneumoniae strain RIVM_C014073

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JNN67_RS20100 Protein ID WP_002892050.1
Coordinates 4084969..4085187 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JNN67_RS20095 Protein ID WP_002892066.1
Coordinates 4084568..4084942 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN67_RS20085 4079720..4080913 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JNN67_RS20090 4080936..4084082 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JNN67_RS20095 4084568..4084942 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JNN67_RS20100 4084969..4085187 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JNN67_RS20105 4085346..4085912 + 567 WP_002892030.1 maltose O-acetyltransferase -
JNN67_RS20110 4085884..4086024 - 141 WP_004147370.1 hypothetical protein -
JNN67_RS20115 4086045..4086515 + 471 WP_002892026.1 YlaC family protein -
JNN67_RS20120 4086490..4087896 - 1407 WP_020316531.1 PLP-dependent aminotransferase family protein -
JNN67_RS20125 4088041..4088739 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
JNN67_RS20130 4088736..4088876 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JNN67_RS20135 4088876..4089139 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T187771 WP_002892050.1 NZ_CP068797:4084969-4085187 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T187771 NZ_CP089992:c6418-6104 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT187771 WP_002892066.1 NZ_CP068797:4084568-4084942 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT187771 NZ_CP089992:c6684-6406 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References