Detailed information of TA system TA187755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4470365..4471185
• Replicon: chromosome
• Accession: NZ_CP068796
• Organism: Escherichia coli strain RIVM_C012087

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN38_RS21520
• Protein ID: WP_001550554.1
• Coordinates: 4470365..4470622 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN38_RS21525
• Protein ID: WP_001519303.1
• Coordinates: 4470634..4471185 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN38_RS21500	4465651..4466757	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN38_RS21505	4466822..4467802	+	981	WP_001519307.1	transposase	-
JNN38_RS21510	4468385..4469626	-	1242	Protein_4214	helicase YjhR	-
JNN38_RS21515	4469689..4469988	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN38_RS21520	4470365..4470622	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN38_RS21525	4470634..4471185	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN38_RS21530	4471237..4471398	+	162	WP_001519302.1	hypothetical protein	-
JNN38_RS21535	4471435..4471983	+	549	WP_001519301.1	hypothetical protein	-
JNN38_RS21540	4472110..4472370	+	261	WP_000084876.1	hypothetical protein	-
JNN38_RS21545	4472408..4472524	+	117	Protein_4221	VOC family protein	-
JNN38_RS21550	4472769..4473890	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN38_RS21555	4473887..4474165	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN38_RS21560	4474177..4475490	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4462849..4471398	8549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T187755 WP_001550554.1 NZ_CP068796:4470365-4470622 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T187755 NZ_CP089986:c4728591-4728307 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTATGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT187755 WP_001519303.1 NZ_CP068796:4470634-4471185 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT187755 NZ_CP089986:c4728823-4728581 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8