Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4407691..4408199 Replicon chromosome
Accession NZ_CP068796
Organism Escherichia coli strain RIVM_C012087

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag JNN38_RS21205 Protein ID WP_001534843.1
Coordinates 4407990..4408199 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A0V9L4L3
Locus tag JNN38_RS21200 Protein ID WP_000063161.1
Coordinates 4407691..4407993 (-) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN38_RS21185 4404219..4406369 + 2151 WP_001366791.1 pyruvate/proton symporter BtsT -
JNN38_RS21190 4406487..4406690 + 204 WP_001534846.1 YbdD/YjiX family protein -
JNN38_RS21195 4406701..4407657 + 957 WP_001534845.1 GTPase -
JNN38_RS21200 4407691..4407993 - 303 WP_000063161.1 BrnA antitoxin family protein Antitoxin
JNN38_RS21205 4407990..4408199 - 210 WP_001534843.1 BrnT family toxin Toxin
JNN38_RS21210 4408295..4409461 + 1167 WP_001534841.1 restriction endonuclease -
JNN38_RS21215 4409525..4411144 + 1620 WP_001550561.1 type I restriction-modification system subunit M -
JNN38_RS21220 4411134..4412444 + 1311 WP_001534837.1 restriction endonuclease subunit S -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(37-93)


Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7952.17 Da        Isoelectric Point: 4.9493

>T187754 WP_001534843.1 NZ_CP068796:c4408199-4407990 [Escherichia coli]
MVDYPKRDAISNINAIIVDTFLYIQLGMATMPMEFEWNANKAKSNRVKHGIRFEDAVLVLDDPQRTEPL

Download         Length: 210 bp

>T187754 NZ_CP089986:c4625287-4624754 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11600.10 Da        Isoelectric Point: 9.4646

>AT187754 WP_000063161.1 NZ_CP068796:c4407993-4407691 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKVLANKFDEDIDYSDIPSSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT187754 NZ_CP089986:c4625564-4625298 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0V9L4L3

References