Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3444199..3444904 Replicon chromosome
Accession NZ_CP068796
Organism Escherichia coli strain RIVM_C012087

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag JNN38_RS16810 Protein ID WP_000539521.1
Coordinates 3444199..3444585 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JNN38_RS16815 Protein ID WP_001280945.1
Coordinates 3444575..3444904 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN38_RS16790 3440203..3440829 + 627 WP_001295292.1 glutathione S-transferase GstB -
JNN38_RS16795 3440826..3441941 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
JNN38_RS16800 3442052..3442435 - 384 WP_000497137.1 biofilm formation regulator BssR -
JNN38_RS16805 3442648..3443973 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JNN38_RS16810 3444199..3444585 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JNN38_RS16815 3444575..3444904 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JNN38_RS16820 3444974..3446302 - 1329 WP_001550887.1 GGDEF domain-containing protein -
JNN38_RS16825 3446310..3448658 - 2349 WP_001550886.1 EAL domain-containing protein -
JNN38_RS16830 3448836..3449747 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T187750 WP_000539521.1 NZ_CP068796:3444199-3444585 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T187750 NZ_CP089986:1864093-1864195 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT187750 WP_001280945.1 NZ_CP068796:3444575-3444904 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT187750 NZ_CP089986:c1864202-1864057 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References