Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 978606..979260 Replicon chromosome
Accession NZ_CP068796
Organism Escherichia coli strain RIVM_C012087

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag JNN38_RS04700 Protein ID WP_000244781.1
Coordinates 978853..979260 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag JNN38_RS04695 Protein ID WP_001564007.1
Coordinates 978606..978872 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN38_RS04675 974694..976127 - 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -
JNN38_RS04680 976172..976483 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
JNN38_RS04685 976647..977306 + 660 WP_000250274.1 hemolysin III family protein -
JNN38_RS04690 977383..978363 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
JNN38_RS04695 978606..978872 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
JNN38_RS04700 978853..979260 + 408 WP_000244781.1 protein YgfX Toxin
JNN38_RS04705 979300..979821 - 522 WP_001055874.1 flavodoxin FldB -
JNN38_RS04710 979933..980829 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JNN38_RS04715 980854..981564 + 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JNN38_RS04720 981570..983303 + 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T187736 WP_000244781.1 NZ_CP068796:978853-979260 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T187736 NZ_CP089980:c5790995-5790714 [Fulvivirga sp. SW1-E11]
ATGATTGAAAGTTTCGGATGTAAGCATACCGAAAAGGTTTGGAACGGAGTCTGGACAAAAAAATGGAGTGATGAAGTTGC
CAATAATGCATTGAGAAAAATGTTTATGATCAATGCGGCAGGTGATATTCAAGACTTGAAAATACCACCATCAAATCGCT
TACATAAGTTGAAAGGAAACATGAAAGAGTATTGGGCTATTAGCATTAATGATCAATGGAGAATAATCTTTCAATGGTCA
AATACGAATGCTTACGATGTTCAAATAATAGATTATCACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT187736 WP_001564007.1 NZ_CP068796:978606-978872 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT187736 NZ_CP089980:c5790714-5790418 [Fulvivirga sp. SW1-E11]
ATGCTGAAAAATAATATACATCCTGGCGAAATTTTAAAATATGAATTCTTAGATCCGATGAATTTGTCAAGTTATAAATT
GTCAAAAGAGCTTGGAATCCAACAAACTCGGATCAGTCAAATAATTAAGGGGAAAAGGTCTGTCACGGCTGACACTGCCA
TTCGGCTGTCTAAATTTTTTGGTACCACCGAAGAGTTTTGGATGAATCTACAGTGTGAATATGATTTAAGAAATGCTCAC
TCTGAAAAGGATAATGAATTTAACAAAATTCAAAAATTCGAAATAGATCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References