Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 161180..161792 Replicon chromosome
Accession NZ_CP068796
Organism Escherichia coli strain RIVM_C012087

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag JNN38_RS00685 Protein ID WP_000833473.1
Coordinates 161180..161365 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag JNN38_RS00690 Protein ID WP_000499744.1
Coordinates 161382..161792 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T187732 WP_000833473.1 NZ_CP068796:161180-161365 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T187732 NZ_CP089979:c319614-319357 [Fulvivirga sp. W9P-11]
ATGATAATTACCTTTACGGAAAATGCCTGGGAGGACTATCTCTATTGGCAGCAGGTAGATAAAAAGATGATCAAAAAGAT
CAATGCGTTGATTAAAGGTATACAGAGAGAGCCCTTTGAGGGAATTGGTAAGCCTGAACCTTTAAAATATGATCTTGCTG
GTTTCTGGTCCAGAAGAATAGATCAGGAGCATAGATTGGTATATCAGGTTAATGATGGTGAATTGCTAATTTATGCTTGT
AGGTATCATTATGATTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT187732 WP_000499744.1 NZ_CP068796:161382-161792 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT187732 NZ_CP089979:c319868-319611 [Fulvivirga sp. W9P-11]
ATGATAGCTGCAAATTTTTCAGAATTTAGAACTGGCCTAAAAAAGTTTTTAGATCAGGTAGAAGACGATAATCAGACTTT
AATTATTAAAAGGAAAAGTGGGAAAGGAAGTGTGGTAATCTCTTTGGATGAATACAATTCTATCATGGAAACCCTGCATC
TGTTAAGTTCCAGGAAAAACTCGGATAGACTTTATGAATCCATTCAACAAATGAAGTCGGGTAAAACTGTTAGCCCCAAG
TTGGATGAGTTAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References