Detailed information of TA system TA187725

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2927836..2928680
• Replicon: chromosome
• Accession: NZ_CP068795
• Organism: Escherichia coli strain RIVM_C011532

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: JNN54_RS14285
• Protein ID: WP_000854686.1
• Coordinates: 2927836..2928219 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: JNN54_RS14290
• Protein ID: WP_001285602.1
• Coordinates: 2928300..2928680 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN54_RS14245	2922838..2923329	-	492	WP_001300785.1	DUF1097 domain-containing protein	-
JNN54_RS14250	2923431..2923985	-	555	WP_001001921.1	molecular chaperone YcdY	-
JNN54_RS14255	2924009..2924746	-	738	WP_000283667.1	zinc-binding phosphatase	-
JNN54_RS14260	2924801..2925739	-	939	WP_000351317.1	glyoxylate/hydroxypyruvate reductase GhrA	-
JNN54_RS14270	2926210..2927052	-	843	WP_001431817.1	DUF4942 domain-containing protein	-
JNN54_RS14275	2927137..2927334	-	198	WP_000839253.1	DUF957 domain-containing protein	-
JNN54_RS14280	2927351..2927839	-	489	WP_001054233.1	hypothetical protein	-
JNN54_RS14285	2927836..2928219	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
JNN54_RS14290	2928300..2928680	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JNN54_RS14295	2928691..2929374	-	684	WP_000086768.1	hypothetical protein	-
JNN54_RS14300	2929393..2929614	-	222	WP_000692298.1	DUF987 domain-containing protein	-
JNN54_RS14305	2929677..2930153	-	477	WP_001186726.1	RadC family protein	-
JNN54_RS14310	2930169..2930654	-	486	WP_000214307.1	antirestriction protein	-
JNN54_RS14315	2930746..2931564	-	819	WP_001234732.1	DUF945 domain-containing protein	-
JNN54_RS14320	2931664..2931897	-	234	WP_001119717.1	DUF905 family protein	-
JNN54_RS14325	2931976..2932431	-	456	WP_001504120.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T187725 WP_000854686.1 NZ_CP068795:c2928219-2927836 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T187725 NZ_CP089975:c534638-534246 [Moraxella sp. ZY190618]
ATGAGATATTTGCTTGACACCAACATTGTGATTGCTTTTCAAAAGCAAAACGCCAATTTATTAAACAAAATGTACCGCTA
TCCCATTGACAGTTTTGCCATTTCAAGCATTGTGCATTTTGAATTGGTGTTTGGGGCATGCAACAGCCAGCAAATGGAAA
AAAATTTCAAAAAAATCAAAGAATTACCCTTTGAAATTTTGGATTTTAATCAAAATGATGGCTTTTATGCAGGGCAAATT
CGCTCCGATTTAAAAGCCAAAGGCACGCCCATCGGAGCTTATGACACATTGATTGCAGGACAAACCCTTGCCAATGATTT
GATTTTAATTACTGACAATATTAAAGAATTTGAGCGAGTAGATGGCTTAAAATTTGAAAATTGGCTACGATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT187725 WP_001285602.1 NZ_CP068795:c2928680-2928300 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT187725 NZ_CP089975:c534886-534635 [Moraxella sp. ZY190618]
ATGAGCCAAACCGCCACCGCAAAACTGTTTTGGACAGGCAACAGCCAAGCCGTCCGCCTACCCAAAGCCTTTCGTTTTGA
AGGCACAGAAGTCAAAATCAAAAAGCAAGGACGGCAGGTAATTATTGAGCCTGTTGTTAATAATTGGGATTTTGTCAAAG
ATTTAGAGCCCTTTGATGAGAGTATGGAGCGAGCCATTGCCGAATTGCGTAACGACCCAATCACCGAAAGAGATTGGAGT
GCGTTTGAATGA