Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2392885..2394473 Replicon chromosome
Accession NZ_CP068795
Organism Escherichia coli strain RIVM_C011532

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag JNN54_RS11620 Protein ID WP_001125439.1
Coordinates 2393151..2394473 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JNN54_RS11615 Protein ID WP_001301023.1
Coordinates 2392885..2393151 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN54_RS11615 2392885..2393151 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JNN54_RS11620 2393151..2394473 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
JNN54_RS11625 2394785..2394993 + 209 Protein_2274 helix-turn-helix transcriptional regulator -
JNN54_RS11630 2395248..2396474 + 1227 Protein_2275 fimbrial biogenesis outer membrane usher protein -
JNN54_RS11635 2396488..2397018 + 531 WP_000876784.1 type 1 fimbrial protein -
JNN54_RS11640 2397031..2397534 + 504 WP_000825452.1 type 1 fimbrial protein -
JNN54_RS11645 2397594..2398508 + 915 WP_044864589.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T187723 WP_001125439.1 NZ_CP068795:2393151-2394473 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T187723 NZ_CP089974:c1742948-1742760 [Moraxella sp. ZY171148]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTACTTTGTTAAGCAAAAAGGCTCTCACAA
GCACTTTAAGCACCCAACCAAAGAAGGCAAAGTAACAATCCCAAACGGTCGTGAAAGCCTACCAATCGGAACGCTAAAAA
GCATTATCAAACAAGCAGGGCTAGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT187723 WP_001301023.1 NZ_CP068795:2392885-2393151 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT187723 NZ_CP089974:c1742710-1742303 [Moraxella sp. ZY171148]
ATGTTATTCCCTATTGCCATTGAAAAACCCGCCAATGAACACGAATGCTACGGTGTGATTGTGCCTGATATTGCGGGGTG
TTTTAGTACAGGCAACACGCCCGATGAAGCCATTAAAAATGCCTATGAAGCCATCGCCCTACATTTGGAGAGTATGGCAG
AAGATGGCGACACCTTGCCCACCGCCAAACCCATTTTCTATCATCAAGACAATGCCGATTATCAAGGCATGATGTGGGCG
GTGGTGGATATGGATATGTCTACCTTTATGGGCAAAGCCGAGAAAATCAATGTTACTTTGCCAAGCCTGCTGATTAGCAA
AATTGACGAAAAAGTAAATGCCCATAAATCGCTTTATAAAAGCCGTTCCAACTATTTGGCACAACTGGCGATGGCGGATT
TGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References