Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 50401..51233 Replicon chromosome
Accession NZ_CP068795
Organism Escherichia coli strain RIVM_C011532

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag JNN54_RS00255 Protein ID WP_000854775.1
Coordinates 50401..50775 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag JNN54_RS00260 Protein ID WP_001285645.1
Coordinates 50865..51233 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN54_RS00230 45763..46686 - 924 WP_000535963.1 carboxylate/amino acid/amine transporter -
JNN54_RS00235 46797..47981 - 1185 WP_001172876.1 sugar efflux transporter -
JNN54_RS00240 48777..49619 - 843 WP_001274548.1 DUF4942 domain-containing protein -
JNN54_RS00245 49704..49901 - 198 WP_000772035.1 DUF957 domain-containing protein -
JNN54_RS00250 49913..50404 - 492 WP_000976825.1 hypothetical protein -
JNN54_RS00255 50401..50775 - 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
JNN54_RS00260 50865..51233 - 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN54_RS00265 51244..51396 - 153 WP_000488333.1 hypothetical protein -
JNN54_RS00270 51396..51617 - 222 WP_000692303.1 DUF987 domain-containing protein -
JNN54_RS00275 51686..52162 - 477 WP_001318130.1 RadC family protein -
JNN54_RS00280 52178..52663 - 486 WP_000213721.1 antirestriction protein -
JNN54_RS00285 52755..53573 - 819 WP_001175173.1 DUF945 domain-containing protein -
JNN54_RS00290 53663..53896 - 234 WP_001278284.1 DUF905 family protein -
JNN54_RS00295 53902..54579 - 678 WP_047671058.1 hypothetical protein -
JNN54_RS00300 54730..55410 - 681 WP_001282911.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T187707 WP_000854775.1 NZ_CP068795:c50775-50401 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T187707 NZ_CP089959:3859914-3860132 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT187707 WP_001285645.1 NZ_CP068795:c51233-50865 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT187707 NZ_CP089959:3859513-3859887 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTAATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References