Detailed information of TA system TA187702

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4445968..4446637
• Replicon: chromosome
• Accession: NZ_CP068771
• Organism: Serratia plymuthica strain UBCF_13

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JK621_RS20725
• Protein ID: WP_212557452.1
• Coordinates: 4446215..4446637 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: JK621_RS20720
• Protein ID: WP_212557451.1
• Coordinates: 4445968..4446234 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK621_RS20695 (JK621_20695)	4441066..4442391	+	1326	WP_212557446.1	MFS transporter	-
JK621_RS20700 (JK621_20700)	4442437..4443045	-	609	WP_212557447.1	HD domain-containing protein	-
JK621_RS20705 (JK621_20705)	4443235..4443912	+	678	WP_212557448.1	hemolysin III family protein	-
JK621_RS20710 (JK621_20710)	4444075..4444572	+	498	WP_212557449.1	DUF2165 domain-containing protein	-
JK621_RS20715 (JK621_20715)	4444627..4445613	-	987	WP_212557450.1	tRNA-modifying protein YgfZ	-
JK621_RS20720 (JK621_20720)	4445968..4446234	+	267	WP_212557451.1	FAD assembly factor SdhE	Antitoxin
JK621_RS20725 (JK621_20725)	4446215..4446637	+	423	WP_212557452.1	protein YgfX	Toxin
JK621_RS20730 (JK621_20730)	4446637..4447332	+	696	WP_212557453.1	two-component system response regulator CreB	-
JK621_RS20735 (JK621_20735)	4447329..4448747	+	1419	WP_212557454.1	two-component system sensor histidine kinase CreC	-
JK621_RS20740 (JK621_20740)	4448832..4450196	+	1365	WP_212557455.1	cell envelope integrity protein CreD	-
JK621_RS20745 (JK621_20745)	4450234..4450752	-	519	WP_126528686.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16425.46 Da
• Isoelectric Point: 10.6512

>T187702 WP_212557452.1 NZ_CP068771:4446215-4446637 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLASKRLSWHGQ
EWLLVKQPWMPRYGILLTLQPIPGKKLRRLWLASDSMGKAEWRHLRQLLQYPSADDDEEP

Nucleotide

• Length: 423 bp

>T187702 NZ_CP089959:728210-728695 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCACAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10527.97 Da
• Isoelectric Point: 4.7921

>AT187702 WP_212557451.1 NZ_CP068771:4445968-4446234 [Serratia plymuthica]
MDINNRARIHWACRRGMRELDISIMPFFEYEYDQLNDTDKALFIRLLENDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT187702 NZ_CP089959:727920-728213 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA