Detailed information of TA system TA187701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 3865065..3865636
• Replicon: chromosome
• Accession: NZ_CP068771
• Organism: Serratia plymuthica strain UBCF_13

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JK621_RS17950
• Protein ID: WP_249337090.1
• Coordinates: 3865065..3865304 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7U3Z6A2
• Locus tag: JK621_RS17955
• Protein ID: WP_013814817.1
• Coordinates: 3865367..3865636 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK621_RS17930 (JK621_17930)	3861231..3861569	-	339	WP_212560231.1	PTS lactose/cellobiose transporter subunit IIA	-
JK621_RS17935 (JK621_17935)	3861925..3862494	+	570	WP_212557068.1	peptidylprolyl isomerase A	-
JK621_RS17940 (JK621_17940)	3862654..3864339	+	1686	WP_212557069.1	sensor histidine kinase	-
JK621_RS17945 (JK621_17945)	3864339..3865064	+	726	WP_013814819.1	two-component system response regulator BtsR	-
JK621_RS17950 (JK621_17950)	3865065..3865304	-	240	WP_249337090.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JK621_RS17955 (JK621_17955)	3865367..3865636	-	270	WP_013814817.1	hypothetical protein	Antitoxin
JK621_RS17960 (JK621_17960)	3865866..3867392	+	1527	WP_212557070.1	DUF853 family protein	-
JK621_RS17965 (JK621_17965)	3867498..3868073	+	576	WP_212557071.1	aminodeoxychorismate synthase component II	-
JK621_RS17970 (JK621_17970)	3868205..3869422	+	1218	WP_212557072.1	aspartate aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-76)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 8678.00 Da
• Isoelectric Point: 7.3145

>T187701 WP_249337090.1 NZ_CP068771:c3865304-3865065 [Serratia plymuthica]
MAIYDYLETKNPAAAIEIDSLISAAATPLSQNPSSGKPGRVPGTREMVIHHSYFLVYELTNGLIIMLAVVHARRQWPAN

Nucleotide

• Length: 240 bp

>T187701 NZ_CP089959:336048-336416 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10394.73 Da
• Isoelectric Point: 7.0169

>AT187701 WP_013814817.1 NZ_CP068771:c3865636-3865367 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVETYF
AERRSKLIR

Nucleotide

• Length: 270 bp

>AT187701 NZ_CP089959:335830-336051 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U3Z6A2