Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3109160..3109750 Replicon chromosome
Accession NZ_CP068771
Organism Serratia plymuthica strain UBCF_13

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JK621_RS14490 Protein ID WP_212556606.1
Coordinates 3109160..3109492 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag JK621_RS14495 Protein ID WP_212556607.1
Coordinates 3109493..3109750 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK621_RS14450 (JK621_14450) 3104800..3105507 + 708 WP_249337073.1 winged helix-turn-helix domain-containing protein -
JK621_RS14455 (JK621_14455) 3105590..3106081 - 492 WP_212556602.1 hypothetical protein -
JK621_RS14460 (JK621_14460) 3106062..3106853 - 792 WP_212556603.1 winged helix-turn-helix domain-containing protein -
JK621_RS25390 3107056..3107214 + 159 Protein_2847 DUF4942 domain-containing protein -
JK621_RS25395 3107225..3107332 + 108 Protein_2848 transcriptional regulator -
JK621_RS14470 (JK621_14470) 3107439..3107819 + 381 WP_212556604.1 hypothetical protein -
JK621_RS14480 (JK621_14480) 3108120..3108908 + 789 WP_212556605.1 DgsA anti-repressor MtfA -
JK621_RS14490 (JK621_14490) 3109160..3109492 - 333 WP_212556606.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JK621_RS14495 (JK621_14495) 3109493..3109750 - 258 WP_212556607.1 antitoxin Antitoxin
JK621_RS14500 (JK621_14500) 3109819..3110003 - 185 Protein_2853 helix-turn-helix domain-containing protein -
JK621_RS14505 (JK621_14505) 3110104..3110994 - 891 WP_212556608.1 oxidoreductase -
JK621_RS14510 (JK621_14510) 3111142..3111840 + 699 WP_212556609.1 RluA family pseudouridine synthase -
JK621_RS14515 (JK621_14515) 3111857..3112396 - 540 WP_212556610.1 DUF2058 domain-containing protein -
JK621_RS14520 (JK621_14520) 3112958..3113257 - 300 WP_212556611.1 hypothetical protein -
JK621_RS14525 (JK621_14525) 3113546..3114601 + 1056 WP_004946469.1 2,3-butanediol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3096783..3113239 16456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11854.61 Da        Isoelectric Point: 7.8382

>T187700 WP_212556606.1 NZ_CP068771:c3109492-3109160 [Serratia plymuthica]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSPASFNQLTRQPVVVPVTSGGNFVRTAGFAVSLDDSGTKTTGVIRCDQPRTI
DMGARCGRRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T187700 NZ_CP089952:c4697763-4697611 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9416.94 Da        Isoelectric Point: 4.4620

>AT187700 WP_212556607.1 NZ_CP068771:c3109750-3109493 [Serratia plymuthica]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCEPHAEMSEEDREWIDAPAM
GKEIL

Download         Length: 258 bp

>AT187700 NZ_CP089952:c4697534-4697400 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References