Detailed information of TA system TA187698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2927236..2927861
• Replicon: chromosome
• Accession: NZ_CP068771
• Organism: Serratia plymuthica strain UBCF_13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JK621_RS13540
• Protein ID: WP_212556447.1
• Coordinates: 2927236..2927418 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JK621_RS13545
• Protein ID: WP_212556448.1
• Coordinates: 2927448..2927861 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK621_RS13530 (JK621_13530)	2922789..2922998	-	210	WP_212556445.1	hypothetical protein	-
JK621_RS13535 (JK621_13535)	2923101..2927072	+	3972	WP_212556446.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
JK621_RS13540 (JK621_13540)	2927236..2927418	+	183	WP_212556447.1	type II toxin-antitoxin system HicA family toxin	Toxin
JK621_RS13545 (JK621_13545)	2927448..2927861	+	414	WP_212556448.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JK621_RS13550 (JK621_13550)	2927894..2928646	-	753	WP_212556449.1	L-cystine ABC transporter ATP-binding protein TcyN	-
JK621_RS13555 (JK621_13555)	2928650..2929312	-	663	WP_013813459.1	cystine ABC transporter permease	-
JK621_RS13560 (JK621_13560)	2929312..2930112	-	801	WP_212556450.1	cystine ABC transporter substrate-binding protein	-
JK621_RS13565 (JK621_13565)	2930226..2931218	-	993	WP_126528272.1	D-cysteine desulfhydrase	-
JK621_RS13570 (JK621_13570)	2931344..2931853	-	510	WP_212556451.1	flagella biosynthesis regulatory protein FliZ	-
JK621_RS13575 (JK621_13575)	2931911..2932633	-	723	WP_212556452.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6936.25 Da
• Isoelectric Point: 11.3081

>T187698 WP_212556447.1 NZ_CP068771:2927236-2927418 [Serratia plymuthica]
VKSAELIRLLEREGWVLERIKGSHHQFKHPRSRLVITVPPPRKDLKPGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T187698 NZ_CP089952:c1234673-1234182 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCTTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15158.91 Da
• Isoelectric Point: 5.1070

>AT187698 WP_212556448.1 NZ_CP068771:2927448-2927861 [Serratia plymuthica]
MFYPAYVHSDHDGSASGFFPDVPGCYFAGDTLDIAFEDAKSALDAHFELLSEDNQAIPRPQAVSFHLAQQNDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQRHPGYGSRSAFLAAAARNELLKVG

Nucleotide

• Length: 414 bp

>AT187698 NZ_CP089952:c1234960-1234670 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA