187689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1452301..1452896 Replicon chromosome
Accession NZ_CP068771
Organism Serratia plymuthica strain UBCF_13

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JK621_RS06880 Protein ID WP_212559174.1
Coordinates 1452301..1452555 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JK621_RS06885 Protein ID WP_249337151.1
Coordinates 1452552..1452896 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK621_RS06860 (JK621_06860) 1448235..1448747 + 513 WP_212559170.1 serine protease inhibitor ecotin -
JK621_RS06865 (JK621_06865) 1448947..1449915 + 969 WP_212559171.1 pyridoxal-phosphate dependent enzyme -
JK621_RS06870 (JK621_06870) 1450334..1450516 + 183 WP_249337150.1 hypothetical protein -
JK621_RS06875 (JK621_06875) 1450933..1451496 + 564 WP_212559173.1 hypothetical protein -
JK621_RS06880 (JK621_06880) 1452301..1452555 + 255 WP_212559174.1 type II toxin-antitoxin system HicA family toxin Toxin
JK621_RS06885 (JK621_06885) 1452552..1452896 + 345 WP_249337151.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JK621_RS06890 (JK621_06890) 1452956..1453189 + 234 WP_212559175.1 hypothetical protein -
JK621_RS06895 (JK621_06895) 1453221..1453474 - 254 Protein_1345 Presumed portal vertex protein -
JK621_RS06905 (JK621_06905) 1453642..1453860 + 219 WP_212559176.1 DNA-binding transcriptional regulator -
JK621_RS06910 (JK621_06910) 1454157..1455845 - 1689 WP_062871318.1 aspartate:alanine antiporter -
JK621_RS06915 (JK621_06915) 1456161..1456550 + 390 WP_212559177.1 inner membrane protein YbjM -
JK621_RS06920 (JK621_06920) 1456593..1456856 - 264 WP_004942515.1 GrxA family glutaredoxin -
JK621_RS06925 (JK621_06925) 1457096..1457410 + 315 WP_212559178.1 YbjC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(56-101)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9554.01 Da        Isoelectric Point: 10.8780

>T187689 WP_212559174.1 NZ_CP068771:1452301-1452555 [Serratia plymuthica]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKDEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Download         Length: 255 bp

>T187689 NZ_CP089948:988787-989548 [Streptococcus pneumoniae TIGR4]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12454.99 Da        Isoelectric Point: 4.3521

>AT187689 WP_249337151.1 NZ_CP068771:1452552-1452896 [Serratia plymuthica]
MMNNTLKIDGHVAVITFDPEIEMFRGEFVGLNGGADFYAYSVEELKTEGSTSLAIFLDECEKDGIAPYKSYSGKVTTRLS
PERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Download         Length: 345 bp

>AT187689 NZ_CP089948:988311-988787 [Streptococcus pneumoniae TIGR4]
ATGATTGGAAAGAACATAAAATCCTTGCGTAAAACACATGACTTAACACAACTCGAATTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
GTCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGATTTGATTCATACGAATATCTATCTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References