187688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 884280..884898 Replicon chromosome
Accession NZ_CP068771
Organism Serratia plymuthica strain UBCF_13

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag JK621_RS04165 Protein ID WP_006322256.1
Coordinates 884280..884483 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag JK621_RS04170 Protein ID WP_004949348.1
Coordinates 884530..884898 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK621_RS04140 (JK621_04140) 879508..880371 - 864 WP_212558749.1 acyl-CoA thioesterase II -
JK621_RS04145 (JK621_04145) 880602..881093 + 492 WP_212558750.1 YbaY family lipoprotein -
JK621_RS04150 (JK621_04150) 881159..881473 - 315 WP_119804832.1 MGMT family protein -
JK621_RS04160 (JK621_04160) 881808..883817 - 2010 WP_212558751.1 right-handed parallel beta-helix repeat-containing protein -
JK621_RS04165 (JK621_04165) 884280..884483 - 204 WP_006322256.1 HHA domain-containing protein Toxin
JK621_RS04170 (JK621_04170) 884530..884898 - 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
JK621_RS04175 (JK621_04175) 885058..885384 - 327 WP_212558752.1 hypothetical protein -
JK621_RS04180 (JK621_04180) 885716..885865 + 150 WP_212558753.1 hypothetical protein -
JK621_RS04185 (JK621_04185) 885862..886575 + 714 WP_212558754.1 ABC transporter ATP-binding protein -
JK621_RS04190 (JK621_04190) 886572..887429 + 858 WP_212558755.1 metal ABC transporter permease -
JK621_RS04195 (JK621_04195) 887455..888333 + 879 WP_212558756.1 metal ABC transporter substrate-binding protein -
JK621_RS04200 (JK621_04200) 888449..888589 - 141 WP_006322277.1 type B 50S ribosomal protein L36 -
JK621_RS04205 (JK621_04205) 888602..888856 - 255 WP_004949355.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T187688 WP_006322256.1 NZ_CP068771:c884483-884280 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T187688 NZ_CP089943:c32592-32248 [Erwinia tracheiphila]
ATGTACGCACTATTTATAGAGCTCTCCAGCTTTGAGAAATACCGGGCAAATTATCTGAATGATGACCAGTTTAGGCTGTT
TCAGAGAATGTTACTGGCCGACCCTGAAAAAGGTGATCTGATCCCGGATACGGGCGGACTGCGTAAGGTACGGTATCGGG
ATGAGCGACGGAATAAAGGTACGCGAGGCGGGATCAGGGTTATCTATTATTGGACTAACGAAAAAGGCCAATTCATCCTG
TTTACTATCTACGATAAAGAACAGCGTGATGATTTGACTAAACAGCAGCGCGACGCCCTGGCAGAGGCGCTGAGCGTAAT
TAAAAAGAGGCTGAAATATGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT187688 WP_004949348.1 NZ_CP068771:c884898-884530 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT187688 NZ_CP089943:c32255-31941 [Erwinia tracheiphila]
ATGAATGAACGCGATATTTACAGTGAACTGATGACGGGCATGCAGGAGTTAAAAGATCACCAAGACGGAAAGATCACGCT
TAAGACATACAAAGTCAGCAAACGAGAACCCGTTACTATCGCGCCGCAGGAACTGCGCGATGTTCGCGAAAAACTTAACT
TGTCACAGGCGGTTTTCGCACACTACCTGCACACAGGAGAGACCACCTATCAGAACTGGGAGCAAGGCAGAGCCAGGCCC
AACGCTCAGGCTGTCCTGCTGATCCGCATGGTGCAGCAGAACCCGGAAACCTTGCAAACCCTCGCTCAGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References