187686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 324069..325618 Replicon chromosome
Accession NZ_CP068771
Organism Serratia plymuthica strain UBCF_13

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JK621_RS01570 Protein ID WP_212558360.1
Coordinates 324320..325618 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JK621_RS01565 Protein ID WP_212558359.1
Coordinates 324069..324317 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK621_RS01535 (JK621_01535) 319493..320209 + 717 WP_212558355.1 LuxR family transcriptional regulator -
JK621_RS01540 (JK621_01540) 320210..320854 - 645 WP_212558356.1 acyl-homoserine-lactone synthase -
JK621_RS25295 322130..322428 + 299 Protein_303 integrase -
JK621_RS01550 (JK621_01550) 322528..322776 + 249 WP_122290155.1 ribbon-helix-helix domain-containing protein -
JK621_RS01555 (JK621_01555) 322780..323055 + 276 WP_212558357.1 type II toxin-antitoxin system RelE/ParE family toxin -
JK621_RS01560 (JK621_01560) 323259..323894 + 636 WP_212558358.1 carbonic anhydrase -
JK621_RS01565 (JK621_01565) 324069..324317 + 249 WP_212558359.1 helix-turn-helix domain-containing protein Antitoxin
JK621_RS01570 (JK621_01570) 324320..325618 + 1299 WP_212558360.1 type II toxin-antitoxin system HipA family toxin Toxin
JK621_RS25300 325740..326981 - 1242 WP_249337132.1 hypothetical protein -
JK621_RS01580 (JK621_01580) 327300..329663 + 2364 WP_212558361.1 class I SAM-dependent DNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48181.18 Da        Isoelectric Point: 5.6384

>T187686 WP_212558360.1 NZ_CP068771:324320-325618 [Serratia plymuthica]
MEKLRVALNGTLVGTLEKHAGGAMSFVYHEEWLAQAGARAISLSLPLQPEPFRGDVVYNFFDNLLPDSELIRSRLQARFR
TVTKQPFDLLSSIGSDCVGAIQLYPEHADMAPVKQVNAVPVSDEEIEQLLLGYREAPLGMEAGTDDFRISLAGAQEKTAL
LWFSDQWCRPQGSTPTSHIIKLPIGHITHNNLDLSESCENEWLCLRIAEQFGLPVAQAELASFGEQKALVVERFDRRWAR
DNSWLIRLPQEDFCQALGIAPALKYEADGGPGIAAAMQLLMGSQQPLLDRDTFFKSQIVFWMLAAIDGHAKNFSLFIEPE
TTYRMTPLYDVLSGYPFMHARGIAPQKAKMAMAVLGQSRHYRWSQILPRHFISTARAVGYSEEKTLQVMAELKAQTESAI
ANVEAMLPDGFPRFVSDAIFAGVRRQAERLPG

Download         Length: 1299 bp

>T187686 NZ_CP089942:4702124-4702408 [Erwinia tracheiphila]
ATGAAAGAAGAACTTAAAAAATTTGATGTTGTTGAATTTCTTGAAGATGAAGAAGATATTCAGGAATATCTTAATGCTGC
AATTGAAGAAGATGATACAAAATACCTTTTTAAAGCATTAGGTAACATAGCCAGAGCAAGAAACATGAGTCAGCTATCTA
AAGAAGTTGGCATGTCCAGAGAGGGAATTTACAAGGCGTTATCCGGTGAAGGGAATCCATCATTCCAGACTGTTTCTAAA
ATCACAAAAGCGCTAGGCTTAAAACTTCACTTCACAGGGGCGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9221.52 Da        Isoelectric Point: 10.4887

>AT187686 WP_212558359.1 NZ_CP068771:324069-324317 [Serratia plymuthica]
MKITSAKMLAHALRNERKKRNQSQSKTADSIGLKQATVSAFENNPDGTRLDTLFKLLAALDLELQVTPRGKPADPKTWDQ
EW

Download         Length: 249 bp

>AT187686 NZ_CP089942:4701826-4702122 [Erwinia tracheiphila]
ATGATCGAGATAAAACGGACGCCGGAAGTTGAAAAATGGCTCAAGTCTTTGAAAGACAGAACGGCAAAAGCAAAAATATT
AATGCGACTTGAACGGATGGAGGACGGGAATTTTGGAGATGTAGAGCCTATTGGTGATGGCTTATCTGAATTGAGAGTTC
ATCAGGGTAAAGGCTACCGTGTGTATTTTGGGAACAAAAATAATAAAATTATTCTCTTGCTTTGCGGTGGAGATAAAAGC
ACACAGCAGGCAGATATCAGAAAGGCAAAACAATTAGCCAAACAGTGGGGTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References