Detailed information of TA system TA187685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 322528..323055
• Replicon: chromosome
• Accession: NZ_CP068771
• Organism: Serratia plymuthica strain UBCF_13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JK621_RS01555
• Protein ID: WP_212558357.1
• Coordinates: 322780..323055 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JK621_RS01550
• Protein ID: WP_122290155.1
• Coordinates: 322528..322776 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK621_RS01530 (JK621_01530)	318219..319289	+	1071	WP_212558354.1	LPS export ABC transporter permease LptG	-
JK621_RS01535 (JK621_01535)	319493..320209	+	717	WP_212558355.1	LuxR family transcriptional regulator	-
JK621_RS01540 (JK621_01540)	320210..320854	-	645	WP_212558356.1	acyl-homoserine-lactone synthase	-
JK621_RS25295	322130..322428	+	299	Protein_303	integrase	-
JK621_RS01550 (JK621_01550)	322528..322776	+	249	WP_122290155.1	ribbon-helix-helix domain-containing protein	Antitoxin
JK621_RS01555 (JK621_01555)	322780..323055	+	276	WP_212558357.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JK621_RS01560 (JK621_01560)	323259..323894	+	636	WP_212558358.1	carbonic anhydrase	-
JK621_RS01565 (JK621_01565)	324069..324317	+	249	WP_212558359.1	helix-turn-helix domain-containing protein	-
JK621_RS01570 (JK621_01570)	324320..325618	+	1299	WP_212558360.1	type II toxin-antitoxin system HipA family toxin	-
JK621_RS25300	325740..326981	-	1242	WP_249337132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10998.39 Da
• Isoelectric Point: 5.1450

>T187685 WP_212558357.1 NZ_CP068771:322780-323055 [Serratia plymuthica]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLIIGSTGLTAHPAIGIQQTRYEPREVRKVLFDDYEVHYELRDTAIY
IVDLWHTKEER

Nucleotide

• Length: 276 bp

>T187685 NZ_CP089942:4701826-4702122 [Erwinia tracheiphila]
ATGATCGAGATAAAACGGACGCCGGAAGTTGAAAAATGGCTCAAGTCTTTGAAAGACAGAACGGCAAAAGCAAAAATATT
AATGCGACTTGAACGGATGGAGGACGGGAATTTTGGAGATGTAGAGCCTATTGGTGATGGCTTATCTGAATTGAGAGTTC
ATCAGGGTAAAGGCTACCGTGTGTATTTTGGGAACAAAAATAATAAAATTATTCTCTTGCTTTGCGGTGGAGATAAAAGC
ACACAGCAGGCAGATATCAGAAAGGCAAAACAATTAGCCAAACAGTGGGGTTTTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9044.42 Da
• Isoelectric Point: 7.2042

>AT187685 WP_122290155.1 NZ_CP068771:322528-322776 [Serratia plymuthica]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTRMLAESERRHQSIQAGLADVDAGRVVSHLDMVDFANRLK
KT

Nucleotide

• Length: 249 bp

>AT187685 NZ_CP089942:4702124-4702408 [Erwinia tracheiphila]
ATGAAAGAAGAACTTAAAAAATTTGATGTTGTTGAATTTCTTGAAGATGAAGAAGATATTCAGGAATATCTTAATGCTGC
AATTGAAGAAGATGATACAAAATACCTTTTTAAAGCATTAGGTAACATAGCCAGAGCAAGAAACATGAGTCAGCTATCTA
AAGAAGTTGGCATGTCCAGAGAGGGAATTTACAAGGCGTTATCCGGTGAAGGGAATCCATCATTCCAGACTGTTTCTAAA
ATCACAAAAGCGCTAGGCTTAAAACTTCACTTCACAGGGGCGTAA