Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta(toxin) |
| Location | 37162..38813 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP068762 | ||
| Organism | Neisseria gonorrhoeae strain 20181204 | ||
Toxin (Protein)
| Gene name | ng_zeta1 | Uniprot ID | D5K9G7 |
| Locus tag | JMJ48_RS11580 | Protein ID | WP_003701905.1 |
| Coordinates | 37608..38813 (-) | Length | 402 a.a. |
Antitoxin (Protein)
| Gene name | ng_epsilon1 | Uniprot ID | D5K9G8 |
| Locus tag | JMJ48_RS11575 | Protein ID | WP_003701903.1 |
| Coordinates | 37162..37593 (-) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMJ48_RS11545 | 32271..33047 | + | 777 | WP_003701891.1 | P-type conjugative transfer protein TrbJ | - |
| JMJ48_RS11550 | 33261..34889 | + | 1629 | WP_003701894.1 | P-type conjugative transfer protein TrbL | - |
| JMJ48_RS11555 | 34936..35454 | + | 519 | WP_025456271.1 | TrbM protein | - |
| JMJ48_RS11560 | 35454..36053 | + | 600 | WP_003701898.1 | TrbN protein | - |
| JMJ48_RS11565 | 36156..36446 | + | 291 | WP_003701899.1 | virulence factor | - |
| JMJ48_RS11570 | 36556..37110 | - | 555 | WP_003701901.1 | recombinase family protein | - |
| JMJ48_RS11575 | 37162..37593 | - | 432 | WP_003701903.1 | hypothetical protein | Antitoxin |
| JMJ48_RS11580 | 37608..38813 | - | 1206 | WP_003701905.1 | toxin | Toxin |
| JMJ48_RS11585 | 38820..39005 | - | 186 | WP_003701907.1 | hypothetical protein | - |
| JMJ48_RS11590 | 39039..40247 | - | 1209 | WP_003701908.1 | zeta toxin family protein | - |
| JMJ48_RS11595 | 40244..40492 | - | 249 | WP_029671738.1 | hypothetical protein | - |
| JMJ48_RS11600 | 40875..41396 | - | 522 | WP_003701911.1 | hypothetical protein | - |
| JMJ48_RS11605 | 41784..41900 | + | 117 | WP_001791010.1 | tetracycline resistance determinant leader peptide | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) | - | 1..42003 | 42003 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 402 a.a. Molecular weight: 44675.53 Da Isoelectric Point: 7.7756
>T187683 WP_003701905.1 NZ_CP068762:c38813-37608 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
Download Length: 1206 bp
>T187683 NZ_CP089942:3506494-3506712 [Erwinia tracheiphila]
ATGACAAACAAAGTTCTTACTAAAACTGATTATCTTATGCGTTTAAGAAAGTGTCGTTCTATCGACACCCTGGAACGCGT
TATAGAAAAGAACAAATACGAATTATCCGACAATGAGCTGGCAGTATTTTATTCTGCTGCTGACCATCGCCTGGCTGAAC
TCACTATGAATAAGCTTTACGATAAGGTGCCTGTTTCAGTCTGGAAATTCATACGTTAG
ATGACAAACAAAGTTCTTACTAAAACTGATTATCTTATGCGTTTAAGAAAGTGTCGTTCTATCGACACCCTGGAACGCGT
TATAGAAAAGAACAAATACGAATTATCCGACAATGAGCTGGCAGTATTTTATTCTGCTGCTGACCATCGCCTGGCTGAAC
TCACTATGAATAAGCTTTACGATAAGGTGCCTGTTTCAGTCTGGAAATTCATACGTTAG
Antitoxin
Download Length: 144 a.a. Molecular weight: 15927.05 Da Isoelectric Point: 4.4211
>AT187683 WP_003701903.1 NZ_CP068762:c37593-37162 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
Download Length: 432 bp
>AT187683 NZ_CP089942:3506088-3506468 [Erwinia tracheiphila]
ATGGACGAGTATTCACCAAAAAGGCATGATGTTGCACAATTAAAATTCTTGTGTGAAAATTTGTACGATGAAAGCATGAC
AACAATAGGTGACAGCCATCATGGATGGATTAACGATCCGACTTCTGCCAGCAATTTACAGCTTAACGATTTGATTGAGC
ACATAGCCTCATTTACCATGAATTACAAAATTAAACATATTGAAGATAGCGATCTGATTAGTCAGATTGATGAATATCTT
GATGACACTTTTATGCTCTTTAGTAATTACGGCATTAATGTTCAGGAACTGCAACGCTGGCGAAAATCAGCTGAAGGGTT
GTTTAGCATTTTTGCAGAGGAGTGCGCTCAAGTTGCCAATCCTGCGAGCCACTCGTTTTAA
ATGGACGAGTATTCACCAAAAAGGCATGATGTTGCACAATTAAAATTCTTGTGTGAAAATTTGTACGATGAAAGCATGAC
AACAATAGGTGACAGCCATCATGGATGGATTAACGATCCGACTTCTGCCAGCAATTTACAGCTTAACGATTTGATTGAGC
ACATAGCCTCATTTACCATGAATTACAAAATTAAACATATTGAAGATAGCGATCTGATTAGTCAGATTGATGAATATCTT
GATGACACTTTTATGCTCTTTAGTAATTACGGCATTAATGTTCAGGAACTGCAACGCTGGCGAAAATCAGCTGAAGGGTT
GTTTAGCATTTTTGCAGAGGAGTGCGCTCAAGTTGCCAATCCTGCGAGCCACTCGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|