Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1582839..1583524 | Replicon | chromosome |
| Accession | NZ_CP068761 | ||
| Organism | Neisseria gonorrhoeae strain 20181204 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | JMJ48_RS08135 | Protein ID | WP_003689143.1 |
| Coordinates | 1583342..1583524 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | JMJ48_RS08130 | Protein ID | WP_003691454.1 |
| Coordinates | 1582839..1583240 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMJ48_RS08075 | 1577883..1578098 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| JMJ48_RS08080 | 1578150..1578641 | - | 492 | WP_017147227.1 | siphovirus Gp157 family protein | - |
| JMJ48_RS08085 | 1578638..1578820 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| JMJ48_RS08090 | 1578960..1579646 | - | 687 | WP_042758540.1 | hypothetical protein | - |
| JMJ48_RS08095 | 1579715..1579876 | - | 162 | WP_003691530.1 | hypothetical protein | - |
| JMJ48_RS08100 | 1579873..1580148 | - | 276 | WP_048654501.1 | hypothetical protein | - |
| JMJ48_RS08105 | 1580303..1580635 | - | 333 | WP_003696914.1 | hypothetical protein | - |
| JMJ48_RS08110 | 1580776..1581063 | - | 288 | WP_202838282.1 | hypothetical protein | - |
| JMJ48_RS08115 | 1581060..1581536 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| JMJ48_RS08120 | 1581569..1581769 | - | 201 | WP_047917349.1 | hypothetical protein | - |
| JMJ48_RS08125 | 1581958..1582740 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| JMJ48_RS08130 | 1582839..1583240 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| JMJ48_RS08135 | 1583342..1583524 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| JMJ48_RS08140 | 1583694..1584512 | - | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| JMJ48_RS08145 | 1584509..1585207 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| JMJ48_RS08150 | 1585446..1586150 | - | 705 | WP_003702453.1 | helix-turn-helix transcriptional regulator | - |
| JMJ48_RS08155 | 1586305..1586493 | + | 189 | WP_080281798.1 | helix-turn-helix domain-containing protein | - |
| JMJ48_RS08160 | 1586705..1586893 | - | 189 | WP_003706568.1 | hypothetical protein | - |
| JMJ48_RS08165 | 1587066..1587293 | + | 228 | WP_003698261.1 | helix-turn-helix domain-containing protein | - |
| JMJ48_RS08170 | 1587411..1588475 | + | 1065 | WP_003689134.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1567654..1601958 | 34304 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T187682 WP_003689143.1 NZ_CP068761:c1583524-1583342 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T187682 NZ_CP089942:3290276-3290455 [Erwinia tracheiphila]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTAAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATTCACAGAAGGACATACCGCAACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTTTAA
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTAAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATTCACAGAAGGACATACCGCAACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTTTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT187682 WP_003691454.1 NZ_CP068761:c1583240-1582839 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT187682 NZ_CP089942:3290478-3290882 [Erwinia tracheiphila]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTGCCTGATATTCCAGGCTGCTTCTCTGG
CGGAGACAACTATCAGGATGCGATTGAGAGCGTCCGCGAGGCTATTGACGCACATATCGAATTACTTGTGGAAGATGGCG
AAGGGTTGCCGGAGGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTAGACGTGGTATGGGCGCTGGTTGAT
GTGGACGTTACCCGATTAATGGGGAAAGCGGAAAAGATAAACGTCACGCTCCCTTCGCTGCTTATCCGCCGTATCGACCA
ATTTGTGGCCGCGCATCCTGAATACGGTAGCCGTTCCGGTTTCCTATCCCGTGTCGCTGCAGATAAAGTCATTGGCAGGA
TCTGA
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTGCCTGATATTCCAGGCTGCTTCTCTGG
CGGAGACAACTATCAGGATGCGATTGAGAGCGTCCGCGAGGCTATTGACGCACATATCGAATTACTTGTGGAAGATGGCG
AAGGGTTGCCGGAGGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTAGACGTGGTATGGGCGCTGGTTGAT
GTGGACGTTACCCGATTAATGGGGAAAGCGGAAAAGATAAACGTCACGCTCCCTTCGCTGCTTATCCGCCGTATCGACCA
ATTTGTGGCCGCGCATCCTGAATACGGTAGCCGTTCCGGTTTCCTATCCCGTGTCGCTGCAGATAAAGTCATTGGCAGGA
TCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|