187681

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 891045..891700 Replicon chromosome
Accession NZ_CP068761
Organism Neisseria gonorrhoeae strain 20181204

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag JMJ48_RS04530 Protein ID WP_003691083.1
Coordinates 891045..891464 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag JMJ48_RS04535 Protein ID WP_003688410.1
Coordinates 891464..891700 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ48_RS04510 886279..887820 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
JMJ48_RS04515 887968..888747 + 780 WP_003688416.1 (Fe-S)-binding protein -
JMJ48_RS04520 888744..889445 + 702 WP_003688414.1 lactate utilization protein C -
JMJ48_RS04525 889442..890896 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
JMJ48_RS04530 891045..891464 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
JMJ48_RS04535 891464..891700 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
JMJ48_RS04540 891906..892103 - 198 WP_033910354.1 IS3 family transposase -
JMJ48_RS04545 892148..892726 - 579 WP_003688041.1 IS3 family transposase -
JMJ48_RS04550 892731..893159 - 429 WP_080229245.1 helix-turn-helix domain-containing protein -
JMJ48_RS04555 893371..893757 + 387 Protein_893 IS110 family transposase -
JMJ48_RS04560 894140..895030 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
JMJ48_RS04565 895041..896207 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
JMJ48_RS04570 896279..896566 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T187681 WP_003691083.1 NZ_CP068761:c891464-891045 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T187681 NZ_CP089942:3262357-3262536 [Erwinia tracheiphila]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
TAAACATCCAATGAAAAAGGGGCTAGTAACGGTAAAACATCCACAAAAGGACATACCGCTACCAACGCTAAAAAGCATCA
AAAAACAGGCGGGGCTTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT187681 WP_003688410.1 NZ_CP068761:c891700-891464 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT187681 NZ_CP089942:3262558-3262953 [Erwinia tracheiphila]
ATGTTATATCCCGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTGCCTGATATTCCTGGCTGCTTCTCTGG
CGGCGACAACTATCAGGATGCGATTGAGAGCGTGCGTGAAGCTATCGACGCACATATCGAATTACTGGTAGAAGATGGTG
AATCGGTGCCGGAGGCGACCAACGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGCGTGGTATGGGCGCTGGTTGAT
GTGGACGTCACCCGGTTAATGGGTAAAGCGGAAAAGATCAACGTCACGCTCCCTTCGCTGCTTATCCGCCGTATCGACCA
ATTTGTGGCCGCGCATCCTGAATACGGTAGCCGTTCCGGTTTCCTGTCCCGTGTCGCTGCAGATAAAGTGTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
AlphaFold DB Q5F881

References