Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 992965..994432 | Replicon | chromosome |
| Accession | NZ_CP068733 | ||
| Organism | Mycoplasmopsis bovis strain J81 isolate J81 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | A0A2N8U3K6 |
| Locus tag | JNG57_RS04310 | Protein ID | WP_014829995.1 |
| Coordinates | 992965..993825 (-) | Length | 287 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | Q934C3 |
| Locus tag | JNG57_RS04315 | Protein ID | WP_013456322.1 |
| Coordinates | 993818..994432 (-) | Length | 205 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JNG57_RS04275 (JNG57_04235) | 988335..988499 | + | 165 | WP_226061498.1 | hypothetical protein | - |
| JNG57_RS04280 (JNG57_04240) | 988743..988880 | + | 138 | WP_226061499.1 | hypothetical protein | - |
| JNG57_RS04285 (JNG57_04245) | 989311..989526 | + | 216 | WP_226061500.1 | hypothetical protein | - |
| JNG57_RS04290 (JNG57_04250) | 989845..990039 | + | 195 | WP_226061501.1 | hypothetical protein | - |
| JNG57_RS04295 (JNG57_04255) | 990259..990792 | + | 534 | WP_235728505.1 | hypothetical protein | - |
| JNG57_RS04300 | 991051..991659 | - | 609 | WP_115276525.1 | variable surface lipoprotein | - |
| JNG57_RS04305 | 991835..992845 | - | 1011 | WP_226061502.1 | variable surface lipoprotein | - |
| JNG57_RS04310 (JNG57_04270) | 992965..993825 | - | 861 | WP_014829995.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JNG57_RS04315 (JNG57_04275) | 993818..994432 | - | 615 | WP_013456322.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| JNG57_RS04655 | 994616..995287 | + | 672 | WP_235728506.1 | variable surface lipoprotein | - |
| JNG57_RS04700 | 995463..995978 | + | 516 | WP_268918964.1 | variable surface lipoprotein | - |
| JNG57_RS04340 (JNG57_04295) | 996507..997940 | + | 1434 | WP_101456648.1 | transposase | - |
| JNG57_RS04345 (JNG57_04300) | 998021..998626 | - | 606 | WP_226061503.1 | variable surface lipoprotein | - |
| JNG57_RS04350 | 998797..999039 | + | 243 | WP_226061504.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 287 a.a. Molecular weight: 33280.36 Da Isoelectric Point: 7.7731
>T187679 WP_014829995.1 NZ_CP068733:c993825-992965 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND
Download Length: 861 bp
>T187679 NZ_CP089942:1414128-1414412 [Erwinia tracheiphila]
GTGTATAAACTCACCGAACGGGCGGCAGAAGACTTCGCCGGGATTTATGACTATACGCTATTAAAATTTGGTGAAGCTCA
GGCAGACCATTATACAGACGCACTTGAGGCATTTTTCGAAACACTGTCCGGAATGCCTGATATGGGGCGGGACTACAATG
CCGTCCCTGGTGTGATGCGCATTGAATTTCAGCGACATATCATTTTTTATACGGTTCGTGATACAGATATTCTGATTGCG
CGTATTTTGCATCAACAGATGAACCATAAACGCCATTTACGTTGA
GTGTATAAACTCACCGAACGGGCGGCAGAAGACTTCGCCGGGATTTATGACTATACGCTATTAAAATTTGGTGAAGCTCA
GGCAGACCATTATACAGACGCACTTGAGGCATTTTTCGAAACACTGTCCGGAATGCCTGATATGGGGCGGGACTACAATG
CCGTCCCTGGTGTGATGCGCATTGAATTTCAGCGACATATCATTTTTTATACGGTTCGTGATACAGATATTCTGATTGCG
CGTATTTTGCATCAACAGATGAACCATAAACGCCATTTACGTTGA
Antitoxin
Download Length: 205 a.a. Molecular weight: 24143.83 Da Isoelectric Point: 9.7617
>AT187679 WP_013456322.1 NZ_CP068733:c994432-993818 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE
Download Length: 615 bp
>AT187679 NZ_CP089942:1413893-1414135 [Erwinia tracheiphila]
ATGGCCAGAACAACAAGCGTTACGATTGGCGAACAGCTCGATTCGTTTATCAGTCGATTAATAGACAGTGGCCGTTACGG
CTCTGCGAGTGAAGTTATGCGCTCTGCTCTGCGGTTGCTGGAGCAACAGGAAACAAACGATGAAGTTGTTCGCCAGGCTG
TTATTGCTGGGCTGGAAAGCGGTGAAAGCTCGCTATCACTGCGGGATATTGCAGCACAAAGAAAACTGAGACATCGTGTA
TAA
ATGGCCAGAACAACAAGCGTTACGATTGGCGAACAGCTCGATTCGTTTATCAGTCGATTAATAGACAGTGGCCGTTACGG
CTCTGCGAGTGAAGTTATGCGCTCTGCTCTGCGGTTGCTGGAGCAACAGGAAACAAACGATGAAGTTGTTCGCCAGGCTG
TTATTGCTGGGCTGGAAAGCGGTGAAAGCTCGCTATCACTGCGGGATATTGCAGCACAAAGAAAACTGAGACATCGTGTA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N8U3K6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q934C3 |