Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 1041650..1043117 | Replicon | chromosome |
| Accession | NZ_CP068731 | ||
| Organism | Mycoplasmopsis bovis strain J228 isolate J228 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | A0A2N8U3K6 |
| Locus tag | JNG60_RS04520 | Protein ID | WP_014829995.1 |
| Coordinates | 1041650..1042510 (-) | Length | 287 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | Q934C3 |
| Locus tag | JNG60_RS04525 | Protein ID | WP_013456322.1 |
| Coordinates | 1042503..1043117 (-) | Length | 205 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JNG60_RS04490 | 1037277..1038191 | + | 915 | WP_226078334.1 | variable surface lipoprotein | - |
| JNG60_RS04495 | 1038367..1038975 | + | 609 | WP_115276525.1 | variable surface lipoprotein | - |
| JNG60_RS04500 (JNG60_04470) | 1039234..1039794 | - | 561 | WP_235728500.1 | variable surface lipoprotein | - |
| JNG60_RS04510 (JNG60_04475) | 1039961..1040677 | - | 717 | WP_226078335.1 | variable surface lipoprotein | - |
| JNG60_RS04515 (JNG60_04480) | 1040853..1041530 | - | 678 | WP_226078336.1 | variable surface lipoprotein | - |
| JNG60_RS04520 (JNG60_04485) | 1041650..1042510 | - | 861 | WP_014829995.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JNG60_RS04525 (JNG60_04490) | 1042503..1043117 | - | 615 | WP_013456322.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| JNG60_RS04530 (JNG60_04495) | 1043300..1043902 | + | 603 | WP_115306019.1 | variable surface lipoprotein | - |
| JNG60_RS04535 | 1044078..1044701 | + | 624 | WP_226078337.1 | variable surface lipoprotein | - |
| JNG60_RS04540 (JNG60_04505) | 1045230..1046663 | + | 1434 | WP_101456648.1 | transposase | - |
| JNG60_RS04545 | 1046671..1047606 | - | 936 | WP_226078338.1 | variable surface lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1030979..1055660 | 24681 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 287 a.a. Molecular weight: 33280.36 Da Isoelectric Point: 7.7731
>T187677 WP_014829995.1 NZ_CP068731:c1042510-1041650 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND
Download Length: 861 bp
>T187677 NZ_CP089942:888399-888689 [Erwinia tracheiphila]
ATGACCTTTAATGTTGAATTTGACGAAAGGGCGTTTAAGGAATGGAATAAGCTCGAAAAGACGATCCGTGAGCAATTCAA
AAAGAAGCTAAAAAAGCTTCAGCAAAACCCTTATGTGGAATCAGCCCGACTGCATGGTGATCTGGCTGGCTGCTTTAAAA
TAAAGCTGAGAGCATCTGGTTTTCGTTTGATTTACAAGGTAATCGATGACGAAATTGTTATATGGGTGGTCGCTGTAGGT
AAACGGGAAGACGAAAAAGCCTATGAAACGGCCCGTAAGCGGCTTTTATAA
ATGACCTTTAATGTTGAATTTGACGAAAGGGCGTTTAAGGAATGGAATAAGCTCGAAAAGACGATCCGTGAGCAATTCAA
AAAGAAGCTAAAAAAGCTTCAGCAAAACCCTTATGTGGAATCAGCCCGACTGCATGGTGATCTGGCTGGCTGCTTTAAAA
TAAAGCTGAGAGCATCTGGTTTTCGTTTGATTTACAAGGTAATCGATGACGAAATTGTTATATGGGTGGTCGCTGTAGGT
AAACGGGAAGACGAAAAAGCCTATGAAACGGCCCGTAAGCGGCTTTTATAA
Antitoxin
Download Length: 205 a.a. Molecular weight: 24143.83 Da Isoelectric Point: 9.7617
>AT187677 WP_013456322.1 NZ_CP068731:c1043117-1042503 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE
Download Length: 615 bp
>AT187677 NZ_CP089942:888155-888409 [Erwinia tracheiphila]
ATGAGCACAATTCAAATCCGCGTTGATGACGAACTGAAAAAAGACGCCTATCAGGCCTTTGAAAAACTGAATCTGTCGCC
TTCGGACGCACTTCGTCTGTTCCTGCGGTATGTTGCAGAGAACGAAAAACTCCCCTTTGCTGAAGTCTCAGTGATGGTGA
GCGAAGATGATGAAGACGCTGATATTCTGGCAGTTGTTCGGGAAAGACTGAAAAATCCGGCAAGACGGATCAGGGTTAAC
GTTGATGACCTTTAA
ATGAGCACAATTCAAATCCGCGTTGATGACGAACTGAAAAAAGACGCCTATCAGGCCTTTGAAAAACTGAATCTGTCGCC
TTCGGACGCACTTCGTCTGTTCCTGCGGTATGTTGCAGAGAACGAAAAACTCCCCTTTGCTGAAGTCTCAGTGATGGTGA
GCGAAGATGATGAAGACGCTGATATTCTGGCAGTTGTTCGGGAAAGACTGAAAAATCCGGCAAGACGGATCAGGGTTAAC
GTTGATGACCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N8U3K6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q934C3 |