Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2396403..2397381 Replicon chromosome
Accession NZ_CP068724
Organism Bacillus cereus strain AFA01

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag JM957_RS12430 Protein ID WP_000624975.1
Coordinates 2396403..2397140 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag JM957_RS12435 Protein ID WP_000237818.1
Coordinates 2397253..2397381 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM957_RS12410 2392045..2392827 + 783 Protein_2362 class I SAM-dependent methyltransferase -
JM957_RS12415 2392985..2394661 - 1677 WP_139256968.1 alpha-keto acid decarboxylase family protein -
JM957_RS12420 2394778..2395260 + 483 WP_072770281.1 MarR family winged helix-turn-helix transcriptional regulator -
JM957_RS12425 2395427..2396164 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
JM957_RS12430 2396403..2397140 + 738 WP_000624975.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
JM957_RS12435 2397253..2397381 + 129 WP_000237818.1 hypothetical protein Antitoxin
JM957_RS12440 2397454..2397630 + 177 WP_065382523.1 stage II sporulation protein SB -
JM957_RS12445 2397650..2398039 - 390 WP_000713862.1 YxeA family protein -
JM957_RS12450 2398251..2399720 + 1470 WP_065382524.1 beta-Ala-His dipeptidase -
JM957_RS12455 2399966..2400775 + 810 WP_065382626.1 C39 family peptidase -
JM957_RS12460 2400801..2401403 + 603 WP_065382625.1 hypothetical protein -
JM957_RS12465 2401646..2401897 - 252 WP_000827560.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28278.98 Da        Isoelectric Point: 8.2998

>T187676 WP_000624975.1 NZ_CP068724:2396403-2397140 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMAIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T187676 NZ_CP089942:314317-314700 [Erwinia tracheiphila]
ATGAAATGGATTAGCGCTCAGGAGGTGATAGCGTTTCATGACCGTCTGCTTACAGCTTTGCCGGGCGTTCAGGGAATGCC
AGAGCCGGGAAGAGCAGAGGCGATCATTTATCGTGTTCAGAACCAGCTTTACTATGAAGGTGTTGAGGATATTCACGAAC
TGGCTGCAATGTATCTTGTCGCTATTTCGCGTGGTCATATCTTCAATGACGGCAATAAGCGAACCGCCTTTTTCGTTGCG
ATGGCTTTTTTAAAGCGCAATGGCATTGATATCCGTGACGAAGGTGATGAACTGGAAGAACTGACGGTATCCGCAGCGAT
GGGGGCAGTAAGCAGCGATGATATTGCTGCTGTTTTGCGCCGATTATCCATCAATCCCCACTAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT187676 WP_000237818.1 NZ_CP068724:2397253-2397381 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT187676 NZ_CP089942:314099-314320 [Erwinia tracheiphila]
ATGCGAACCTATACCACATCTCAGGCCCGGCAAAATATTGCCGAAGTAATGGAAGCGGCTACGGCTGGTGAGCCTGTAGA
AATAACTCGCCGCGATGGCTCTGCCGCTGTGCTTATCAGCCGAGATGATTTCAACGCGTGGCAGGAAGCAAAGCTGGATG
CTGAATTTGCCGAAATTATGGGGCGACACGGTCGTACCATTAAGGCGCTGGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References