187674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2489823..2490801 Replicon chromosome
Accession NZ_CP068719
Organism Bacillus cereus strain 21155

Toxin (Protein)


Gene name spoIISA Uniprot ID B7IX38
Locus tag JM956_RS12955 Protein ID WP_000624981.1
Coordinates 2489823..2490560 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag JM956_RS12960 Protein ID WP_000237818.1
Coordinates 2490673..2490801 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM956_RS12930 2485418..2485825 + 408 WP_000072493.1 VOC family protein -
JM956_RS12935 2486160..2486942 + 783 Protein_2466 class I SAM-dependent methyltransferase -
JM956_RS12940 2487100..2488091 - 992 Protein_2467 hypothetical protein -
JM956_RS12945 2488199..2488681 + 483 WP_098518590.1 MarR family winged helix-turn-helix transcriptional regulator -
JM956_RS12950 2488848..2489585 + 738 WP_202822718.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
JM956_RS12955 2489823..2490560 + 738 WP_000624981.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
JM956_RS12960 2490673..2490801 + 129 WP_000237818.1 hypothetical protein Antitoxin
JM956_RS12965 2490874..2491050 + 177 WP_000852629.1 stage II sporulation protein SB -
JM956_RS12970 2491069..2491458 - 390 Protein_2473 YxeA family protein -
JM956_RS12975 2491670..2493139 + 1470 WP_202822719.1 aminoacyl-histidine dipeptidase -
JM956_RS12980 2493384..2494193 + 810 WP_202822720.1 C39 family peptidase -
JM956_RS12985 2494219..2494821 + 603 WP_076876379.1 hypothetical protein -
JM956_RS12990 2495011..2495262 - 252 WP_000827560.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28335.09 Da        Isoelectric Point: 8.2998

>T187674 WP_000624981.1 NZ_CP068719:2489823-2490560 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T187674 NZ_CP089942:c288237-287962 [Erwinia tracheiphila]
GTGCAATGGGTTAAATGGAAGGAATCAGCGCTCAACGATTTAGCCGACATTATTGATTATATTGAACAATATAACCCTGT
TGCGAGTCGAAAATTACATCAACAGATAGTACATGTAGCCGAAAACCTCCCTCAGCATCCTTATCTTTATCGTCCTGGCA
GAGTTGCTGGCACTCGCGAAATCGTTGTCCATCCGAACTATTTAGTTGTCTACCACATTGATGATTTTGAAATAGAAATT
CTGGGGGTATTGCATGCTCGCCAGGAATATCCGTAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT187674 WP_000237818.1 NZ_CP068719:2490673-2490801 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT187674 NZ_CP089942:c288424-288224 [Erwinia tracheiphila]
ATGACCACTAAACTGTCCCCCATCGTGTCTGAATTTGAGACTCAGGAGCAGGCTGACAGCTATGATCGCTGGTTCCGGGC
TAAGGTTCAGGTCGCGCTGGACGACCCACGTCCGGGTATTCCTCACGATGATGCAATGGCAAAGCTGGAAGCAATGCTGG
AAGAGAGACGGACCTTGAGGGCAAAGCGTGCAATGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6D1SWF1

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References