187673

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 233853..234495 Replicon chromosome
Accession NZ_CP068719
Organism Bacillus cereus strain 21155

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag JM956_RS01335 Protein ID WP_000635965.1
Coordinates 234145..234495 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag JM956_RS01330 Protein ID WP_000004570.1
Coordinates 233853..234140 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM956_RS01305 229170..230132 + 963 WP_000961160.1 UV DNA damage repair endonuclease UvsE -
JM956_RS01310 230125..230697 - 573 WP_000908521.1 rhomboid family intramembrane serine protease -
JM956_RS01315 230791..231150 + 360 WP_000583417.1 holo-ACP synthase -
JM956_RS01320 231307..232257 + 951 WP_202822764.1 outer membrane lipoprotein carrier protein LolA -
JM956_RS01325 232375..233544 + 1170 WP_000390611.1 alanine racemase -
JM956_RS01330 233853..234140 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
JM956_RS01335 234145..234495 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
JM956_RS01340 234563..236731 + 2169 WP_000426234.1 RNA-binding transcriptional accessory protein -
JM956_RS01345 236789..236905 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
JM956_RS01350 237101..237559 + 459 WP_000344238.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T187673 WP_000635965.1 NZ_CP068719:234145-234495 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T187673 NZ_CP089940:4860379-4860663 [Erwinia tracheiphila]
ATGAAAGAAGAACTTAAAAAATTTGATGTTGTTGAATTTCTTGAAGATGAAGAAGATATTCAGGAATATCTTAATGCTGC
AATTGAAGAAGATGATACAAAATACCTTTTTAAAGCATTAGGTAACATAGCCAGAGCAAGAAACATGAGTCAGCTATCTA
AAGAAGTTGGCATGTCCAGAGAGGGAATTTACAAGGCGTTATCCGGTGAAGGGAATCCATCATTCCAGACTGTTTCTAAA
ATCACAAAAGCGCTAGGCTTAAAACTTCACTTCACAGGGGCGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT187673 WP_000004570.1 NZ_CP068719:233853-234140 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT187673 NZ_CP089940:4860081-4860377 [Erwinia tracheiphila]
ATGATCGAGATAAAACGGACGCCGGAAGTTGAAAAATGGCTCAAGTCTTTGAAAGACAGAACGGCAAAAGCAAAAATATT
AATGCGACTTGAACGGATGGAGGACGGGAATTTTGGAGATGTAGAGCCTATTGGTGATGGCTTATCTGAATTGAGAGTTC
ATCAGGGTAAAGGCTACCGTGTGTATTTTGGGAACAAAAATAATAAAATTATTCTCTTGCTTTGCGGTGGAGATAAAAGC
ACACAGCAGGCAGATATCAGAAAGGCAAAACAATTAGCCAAACAGTGGGGTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References