Detailed information of TA system TA187670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 14215..14711
• Replicon: plasmid p14AME19-3
• Accession: NZ_CP068715
• Organism: Staphylococcus pseudoxylosus strain 14AME19

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JMB28_RS14105
• Protein ID: WP_202847979.1
• Coordinates: 14439..14711 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JMB28_RS14100
• Protein ID: WP_202847978.1
• Coordinates: 14215..14442 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMB28_RS14080	10101..12011	-	1911	WP_202847975.1	threonine--tRNA ligase	-
JMB28_RS14085	12347..12550	-	204	Protein_15	helix-turn-helix domain-containing protein	-
JMB28_RS14090	13064..13651	-	588	WP_202847976.1	signal peptidase I	-
JMB28_RS14095	13762..14058	+	297	WP_202847977.1	DUF3139 domain-containing protein	-
JMB28_RS14100	14215..14442	+	228	WP_202847978.1	toxin-antitoxin system, antitoxin component	Antitoxin
JMB28_RS14105	14439..14711	+	273	WP_202847979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JMB28_RS14110	14909..15583	+	675	WP_001105987.1	IS6-like element IS257 family transposase	-
JMB28_RS14115	15984..16292	-	309	WP_202847980.1	hypothetical protein	-
JMB28_RS14120	16305..16499	+	195	WP_202847981.1	hypothetical protein	-
JMB28_RS14125	16787..17005	+	219	WP_202847982.1	hypothetical protein	-
JMB28_RS14130	17276..17455	+	180	WP_202847983.1	hypothetical protein	-
JMB28_RS14135	17468..17983	-	516	WP_202847984.1	hypothetical protein	-
JMB28_RS14140	18176..18466	+	291	WP_202847985.1	helix-turn-helix domain-containing protein	-
JMB28_RS14145	19170..19334	+	165	WP_145579271.1	ribbon-helix-helix protein, CopG family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	fosD	-	1..46422	46422
	-	flank	IS/Tn	-	-	14909..15583	674

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10526.36 Da
• Isoelectric Point: 10.8626

>T187670 WP_202847979.1 NZ_CP068715:14439-14711 [Staphylococcus pseudoxylosus]
MKYSLKISKKTNKTLSKMDKPTRNLLLKWMNNNIHNTDNPRLHGKSLRGELSGLWRYRVGKYRIIVEIQDDELVVLAIDV
GIRGSIYNKK

Nucleotide

• Length: 273 bp

>T187670 NZ_CP089940:c3950964-3950581 [Erwinia tracheiphila]
ATGAAATGGATTAGCGCTCAGGAGGTGATAGCGTTTCATGACCGTCTGCTTACAGCTTTGCCGGGCGTTCAGGGAATGCC
AGAGCCGGGAAGAGCAGAGGCGATCATTTATCGTGTTCAGAACCAGCTTTACTATGAAGGTGTTGAGGATATTCACGAAC
TGGCTGCAATGTATCTTGTCGCTATTTCGCGTGGTCATATCTTCAATGACGGCAATAAGCGAACCGCCTTTTTCGTTGCG
ATGGCTTTTTTAAAGCGCAATGGCATTGATATCCGTGACGAAGGTGATGAACTGGAAGAACTGACGGTATCCGCAGCGAT
GGGGGCAGTAAGCAGCGATGATATTGCTGCTGTTTTGCGCCGATTATCCATCAATCCCCACTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8786.85 Da
• Isoelectric Point: 3.9956

>AT187670 WP_202847978.1 NZ_CP068715:14215-14442 [Staphylococcus pseudoxylosus]
MATITVRVSDEEKEFLEYMSNFLGLSLSKIIKEYTIEDLENIYDAKVGDDALKEYRENGEQALYIDDVMKQWNVN

Nucleotide

• Length: 228 bp

>AT187670 NZ_CP089940:c3951182-3950961 [Erwinia tracheiphila]
ATGCGAACCTATACCACATCTCAGGCCCGGCAAAATATTGCCGAAGTAATGGAAGCGGCTACGGCTGGTGAGCCTGTAGA
AATAACTCGCCGCGATGGCTCTGCCGCTGTGCTTATCAGCCGAGATGATTTCAACGCGTGGCAGGAAGCAAAGCTGGATG
CTGAATTTGCCGAAATTATGGGGCGACACGGTCGTACCATTAAGGCGCTGGCCGACAGATGA