Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 14215..14711 Replicon plasmid p14AME19-3
Accession NZ_CP068715
Organism Staphylococcus pseudoxylosus strain 14AME19

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JMB28_RS14105 Protein ID WP_202847979.1
Coordinates 14439..14711 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMB28_RS14100 Protein ID WP_202847978.1
Coordinates 14215..14442 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMB28_RS14080 10101..12011 - 1911 WP_202847975.1 threonine--tRNA ligase -
JMB28_RS14085 12347..12550 - 204 Protein_15 helix-turn-helix domain-containing protein -
JMB28_RS14090 13064..13651 - 588 WP_202847976.1 signal peptidase I -
JMB28_RS14095 13762..14058 + 297 WP_202847977.1 DUF3139 domain-containing protein -
JMB28_RS14100 14215..14442 + 228 WP_202847978.1 toxin-antitoxin system, antitoxin component Antitoxin
JMB28_RS14105 14439..14711 + 273 WP_202847979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMB28_RS14110 14909..15583 + 675 WP_001105987.1 IS6-like element IS257 family transposase -
JMB28_RS14115 15984..16292 - 309 WP_202847980.1 hypothetical protein -
JMB28_RS14120 16305..16499 + 195 WP_202847981.1 hypothetical protein -
JMB28_RS14125 16787..17005 + 219 WP_202847982.1 hypothetical protein -
JMB28_RS14130 17276..17455 + 180 WP_202847983.1 hypothetical protein -
JMB28_RS14135 17468..17983 - 516 WP_202847984.1 hypothetical protein -
JMB28_RS14140 18176..18466 + 291 WP_202847985.1 helix-turn-helix domain-containing protein -
JMB28_RS14145 19170..19334 + 165 WP_145579271.1 ribbon-helix-helix protein, CopG family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid fosD - 1..46422 46422
- flank IS/Tn - - 14909..15583 674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10526.36 Da        Isoelectric Point: 10.8626

>T187670 WP_202847979.1 NZ_CP068715:14439-14711 [Staphylococcus pseudoxylosus]
MKYSLKISKKTNKTLSKMDKPTRNLLLKWMNNNIHNTDNPRLHGKSLRGELSGLWRYRVGKYRIIVEIQDDELVVLAIDV
GIRGSIYNKK

Download         Length: 273 bp

>T187670 NZ_CP089940:c3950964-3950581 [Erwinia tracheiphila]
ATGAAATGGATTAGCGCTCAGGAGGTGATAGCGTTTCATGACCGTCTGCTTACAGCTTTGCCGGGCGTTCAGGGAATGCC
AGAGCCGGGAAGAGCAGAGGCGATCATTTATCGTGTTCAGAACCAGCTTTACTATGAAGGTGTTGAGGATATTCACGAAC
TGGCTGCAATGTATCTTGTCGCTATTTCGCGTGGTCATATCTTCAATGACGGCAATAAGCGAACCGCCTTTTTCGTTGCG
ATGGCTTTTTTAAAGCGCAATGGCATTGATATCCGTGACGAAGGTGATGAACTGGAAGAACTGACGGTATCCGCAGCGAT
GGGGGCAGTAAGCAGCGATGATATTGCTGCTGTTTTGCGCCGATTATCCATCAATCCCCACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.85 Da        Isoelectric Point: 3.9956

>AT187670 WP_202847978.1 NZ_CP068715:14215-14442 [Staphylococcus pseudoxylosus]
MATITVRVSDEEKEFLEYMSNFLGLSLSKIIKEYTIEDLENIYDAKVGDDALKEYRENGEQALYIDDVMKQWNVN

Download         Length: 228 bp

>AT187670 NZ_CP089940:c3951182-3950961 [Erwinia tracheiphila]
ATGCGAACCTATACCACATCTCAGGCCCGGCAAAATATTGCCGAAGTAATGGAAGCGGCTACGGCTGGTGAGCCTGTAGA
AATAACTCGCCGCGATGGCTCTGCCGCTGTGCTTATCAGCCGAGATGATTTCAACGCGTGGCAGGAAGCAAAGCTGGATG
CTGAATTTGCCGAAATTATGGGGCGACACGGTCGTACCATTAAGGCGCTGGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References