Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1020340..1020869 Replicon chromosome
Accession NZ_CP068712
Organism Staphylococcus pseudoxylosus strain 14AME19

Toxin (Protein)


Gene name mazF Uniprot ID A0A418IEU1
Locus tag JMB28_RS04760 Protein ID WP_039069737.1
Coordinates 1020507..1020869 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1D4YKY9
Locus tag JMB28_RS04755 Protein ID WP_017722121.1
Coordinates 1020340..1020510 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMB28_RS04730 1016116..1016595 + 480 WP_039069742.1 PH domain-containing protein -
JMB28_RS04735 1016588..1018096 + 1509 WP_039069741.1 PH domain-containing protein -
JMB28_RS04740 1018083..1018574 + 492 WP_039069740.1 PH domain-containing protein -
JMB28_RS04745 1018637..1018999 + 363 WP_039069739.1 holo-ACP synthase -
JMB28_RS04750 1019104..1020252 + 1149 WP_039069738.1 alanine racemase -
JMB28_RS04755 1020340..1020510 + 171 WP_017722121.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JMB28_RS04760 1020507..1020869 + 363 WP_039069737.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JMB28_RS04765 1020988..1021125 - 138 WP_157822577.1 hypothetical protein -
JMB28_RS04770 1021222..1022223 + 1002 WP_039069736.1 PP2C family protein-serine/threonine phosphatase -
JMB28_RS04775 1022303..1022629 + 327 WP_029377954.1 anti-sigma factor antagonist -
JMB28_RS04780 1022631..1023113 + 483 WP_039069735.1 anti-sigma B factor RsbW -
JMB28_RS04785 1023088..1023858 + 771 WP_039069734.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13528.77 Da        Isoelectric Point: 10.3172

>T187665 WP_039069737.1 NZ_CP068712:1020507-1020869 [Staphylococcus pseudoxylosus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSEKKMKEVNIAIDISLGLHNIRNNKS

Download         Length: 363 bp

>T187665 NZ_CP089940:2172281-2172592 [Erwinia tracheiphila]
ATGCCACAGGTAATCGTCTCCGCACTGGCGCAGCGGGATTTACAGCGCCTGCAAGACTTTCTCAAAACCAAAAACCGGCT
GGCAGCCAGAAAAGCCGGTGAGGTAATCGTCCGGGCTATACAGCAGCTGAAGACACAGCCGGATATGGGTCGCCCGGTTT
CGCTTCTCCCGCTGGAATACCAGGAACTGGTGATCGGATTTGGCGACAGTGGTTATGTCATGCTCTATCGCCACGACCGG
GAAACAGACCAGATAGTGATCCTGACAGCCCTACACCAGAAAGAAGCCGGCTATCGCGGCCTGCAGGAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6305.92 Da        Isoelectric Point: 4.0121

>AT187665 WP_017722121.1 NZ_CP068712:1020340-1020510 [Staphylococcus pseudoxylosus]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT187665 NZ_CP089940:2172015-2172293 [Erwinia tracheiphila]
ATGTCAGCAGCAACATCCATCAGGCTTGATGATGAACTCAAAGACCGCCTGAAAACTCTTGCCGATGATCGCCACCGTTC
CGCTCATGCTTTGATGCTGGAAGCGATCACCGAATACATCGACCGCGAAGAAAAGCGCAGCCAGTACCTCCGGGATGGGC
AGGCCGCATGGCAGCACTATCAGGAAACCGGTCTGCACCTGAGCGCCGAAGAAGTGGAATCCTGGATAGATACCTGGGGA
ACTGAGAATGAGCAGGATGCTCCGTCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418IEU1

Antitoxin

Source ID Structure
AlphaFold DB A0A1D4YKY9

References