Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2567954..2569710 Replicon chromosome
Accession NZ_CP068710
Organism Burkholderia thailandensis strain AW34-19p

Toxin (Protein)


Gene name doc Uniprot ID Q2T555
Locus tag JMY07_RS27810 Protein ID WP_009900384.1
Coordinates 2568805..2569710 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q2T556
Locus tag JMY07_RS27805 Protein ID WP_009897321.1
Coordinates 2567954..2568808 (-) Length 285 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMY07_RS27785 2563174..2564664 - 1491 WP_009897313.1 aldehyde dehydrogenase -
JMY07_RS27790 2564686..2565501 - 816 WP_009897315.1 aspartate dehydrogenase -
JMY07_RS27795 2565494..2567167 - 1674 WP_009897317.1 thiamine pyrophosphate-binding protein -
JMY07_RS27800 2567160..2567957 - 798 WP_009897318.1 SDR family oxidoreductase -
JMY07_RS27805 2567954..2568808 - 855 WP_009897321.1 IclR family transcriptional regulator Antitoxin
JMY07_RS27810 2568805..2569710 - 906 WP_009900384.1 alpha/beta fold hydrolase Toxin
JMY07_RS27815 2569727..2570254 - 528 WP_009897327.1 cupin domain-containing protein -
JMY07_RS27820 2570293..2571063 - 771 WP_009897331.1 SDR family oxidoreductase -
JMY07_RS27825 2571060..2572127 - 1068 WP_009897333.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
JMY07_RS27830 2572162..2572473 - 312 WP_009897334.1 hypothetical protein -
JMY07_RS27835 2572475..2572792 - 318 WP_009897336.1 non-heme iron oxygenase ferredoxin subunit -
JMY07_RS27840 2573227..2574315 + 1089 WP_009897338.1 porin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(54-285)

Antitoxin

(143-265)


Sequences


Toxin        


Download         Length: 302 a.a.        Molecular weight: 30752.67 Da        Isoelectric Point: 8.4768

>T187662 WP_009900384.1 NZ_CP068710:c2569710-2568805 [Burkholderia thailandensis]
MSAISTTTTDASATPFAALLERFAERRAAAGGARTIGYREAGAAYAAHAGRDPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGVSSRVAADSPVASDYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARQAGERLSGLLLISPAGGYGGAPA
DVRAERRDSRLALLASLGPQGLAAERSANMLSAQASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLAHYRGRVAV
AVGADDTITPPAACERIARAAGAGLQVIPRAGHAGYVEAPDAYNALIDAFCRQCDGSRGAA

Download         Length: 906 bp

>T187662 NZ_CP089940:c1347099-1346824 [Erwinia tracheiphila]
GTGCAATGGGTTAAATGGAAGGAATCAGCGCTCAACGATTTAGCCGACATTATTGATTATATTGAACAATATAACCCTGT
TGCGAGTCGAAAATTACATCAACAGATAGTACATGTAGCCGAAAACCTCCCTCAGCATCCTTATCTTTATCGTCCTGGCA
GAGTTGCTGGCACTCGCGAAATCGTTGTCCATCCGAACTATTTAGTTGTCTACCACATTGATGATTTTGAAATAGAAATT
CTGCGGGTATTGCATGCTCGCCAGGAATATCCGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31148.57 Da        Isoelectric Point: 6.9978

>AT187662 WP_009897321.1 NZ_CP068710:c2568808-2567954 [Burkholderia thailandensis]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLTLAELRTLYPERALERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDASLVADGLIDKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT187662 NZ_CP089940:c1347286-1347086 [Erwinia tracheiphila]
ATGACCACTAAACTGTCCCCCATCGTGTCTGAATTTGAGACTCAGGAGCAGGCTGACAGCTATGATCGCTGGTTCCGGGC
TAAGGTTCAGGTCGCGCTGGACGACCCACGTCCGGGTATTCCTCACGATGATGCAATGGCAAAGCTGGAAGCAATGCTGG
AAGAGAGACGGACCTTGAGGGCAAAGCGTGCAATGGGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q2T555


Antitoxin

Source ID Structure
AlphaFold DB Q2T556

References