Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1329794..1330433 Replicon chromosome
Accession NZ_CP068710
Organism Burkholderia thailandensis strain AW34-19p

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag JMY07_RS23110 Protein ID WP_009893919.1
Coordinates 1329794..1329973 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q2T3Q7
Locus tag JMY07_RS23115 Protein ID WP_011401461.1
Coordinates 1330017..1330433 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMY07_RS23085 1325183..1326163 + 981 WP_043037760.1 DUF3644 domain-containing protein -
JMY07_RS23090 1326485..1327060 + 576 WP_009893925.1 recombinase family protein -
JMY07_RS23095 1327131..1328246 - 1116 WP_009893924.1 DUF3396 domain-containing protein -
JMY07_RS23100 1328256..1328990 - 735 WP_011401463.1 VRR-NUC domain-containing protein -
JMY07_RS23105 1328987..1329514 - 528 WP_011401462.1 PAAR domain-containing protein -
JMY07_RS23110 1329794..1329973 + 180 WP_009893919.1 type II toxin-antitoxin system HicA family toxin Toxin
JMY07_RS23115 1330017..1330433 + 417 WP_011401461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMY07_RS23120 1330862..1331359 - 498 WP_011401460.1 hypothetical protein -
JMY07_RS23125 1331978..1332550 - 573 WP_009893915.1 site-specific integrase -
JMY07_RS23130 1332603..1333337 - 735 WP_009893914.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1310863..1330433 19570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T187661 WP_009893919.1 NZ_CP068710:1329794-1329973 [Burkholderia thailandensis]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T187661 NZ_CP089935:c32593-32249 [Erwinia tracheiphila]
ATGTACGCACTATTTATAGAGCTCTCCAGCTTTGAGAAATACCGGGCAAATTATCTGAATGATGACCAGTTTAGGCTGTT
TCAGAGAATGTTACTGGCCGACCCTGAAAAAGGTGATCTGATCCCGGATACGGGCGGACTGCGTAAGGTACGGTATCGGG
ATGAGCGACGGAATAAAGGTACGCGAGGCGGGATCAGGGTTATCTATTATTGGACTAACGAAAAAGGCCAATTCATCCTG
TTTACTATCTACGATAAAGAACAGCGTGATGATTTGACTAAACAGCAGCGCGACGCCCTGGCAGAGGCGCTGAGCGTAAT
TAAAAAGAGGCTGAAATATGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.03 Da        Isoelectric Point: 4.6944

>AT187661 WP_011401461.1 NZ_CP068710:1330017-1330433 [Burkholderia thailandensis]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGDDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT187661 NZ_CP089935:c32256-31942 [Erwinia tracheiphila]
ATGAATGAACGCGATATTTACAGTGAACTGATGACGGGCATGCAGGAGTTAAAAGATCACCAAGACGGAAAGATCACGCT
TAAGACATACAAAGTCAGCAAACGAGAACCCGTTACTATCGCGCCGCAGGAACTGCGCGATGTTCGCGAAAAACTTAACT
TGTCACAGGCGGTTTTCGCACACTACCTGCACACAGGAGAGACCACCTATCAGAACTGGGAGCAAGGCAGAGCCAGGCCC
AACGCTCAGGCTGTCCTGCTGATCCGCATGGTGCAGCAGAACCCGGAAACCTTGCAAACCCTCGCTCAGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4C26
PDB 6G26

Antitoxin

Source ID Structure
AlphaFold DB Q2T3Q7

References