Detailed information of TA system TA187660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1958492..1959098
• Replicon: chromosome
• Accession: NZ_CP068708
• Organism: Streptococcus suis strain ID33329

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G7SEL6
• Locus tag: JM964_RS09430
• Protein ID: WP_014638724.1
• Coordinates: 1958492..1958821 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: JM964_RS09435
• Protein ID: WP_105115298.1
• Coordinates: 1958811..1959098 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JM964_RS09410	1953842..1955572	-	1731	WP_041179291.1	membrane protein	-
JM964_RS09415	1955775..1956647	-	873	WP_014638721.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
JM964_RS09420	1956825..1957994	-	1170	WP_014638722.1	hypothetical protein	-
JM964_RS09425	1958011..1958394	-	384	WP_014638723.1	DUF2513 domain-containing protein	-
JM964_RS09430	1958492..1958821	-	330	WP_014638724.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JM964_RS09435	1958811..1959098	-	288	WP_105115298.1	toxin-antitoxin system antitoxin subunit	Antitoxin
JM964_RS09440	1959196..1959564	-	369	WP_024401195.1	hypothetical protein	-
JM964_RS09445	1959557..1960126	-	570	WP_105105440.1	ribonuclease M5	-
JM964_RS09450	1960110..1960892	-	783	WP_105105439.1	TatD family hydrolase	-
JM964_RS09455	1960999..1961136	-	138	WP_002939016.1	50S ribosomal protein L34	-
JM964_RS09460	1961304..1962299	-	996	WP_024395756.1	protein jag	-
JM964_RS09465	1962319..1963131	-	813	WP_202847568.1	YidC/Oxa1 family membrane protein insertase	-
JM964_RS09470	1963115..1963474	-	360	WP_004194560.1	ribonuclease P protein component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-96)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12607.51 Da
• Isoelectric Point: 5.7640

>T187660 WP_014638724.1 NZ_CP068708:c1958821-1958492 [Streptococcus suis]
MEFESYSVILAPAVEKELADIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVEKEVRVGHLFATKSDYVKLLK

Nucleotide

• Length: 330 bp

>T187660 NZ_CP089935:17164-17451 [Erwinia tracheiphila]
ATGACCTATCGGGTGAAGTTCAGAACGGATGCGCTGAAAGAATGGAATAATCTTGATAAAGCTATTCAGCAGCAGTTTGT
CCGGAAGCTAAAGAAATGTGCGGAGAATCCTCATATCCCTTCCGCAAAGTTACGAGGAATGCCCGATTGCTATAAAATCA
AACTGCAAGCATCGGGCTTCAGGCTGGTTTATCAGGTTATTAACGACGAACTCATCATTGCTGTGGTCGCTGTAGGCAAA
CGTGAGCACAGCAAAGTTTATAATCTGGCCAGCAAACGGCTAAGATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10922.59 Da
• Isoelectric Point: 4.4356

>AT187660 WP_105115298.1 NZ_CP068708:c1959098-1958811 [Streptococcus suis]
MITIKKNAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GQGISLEIVKEKYGI

Nucleotide

• Length: 288 bp

>AT187660 NZ_CP089935:16916-17167 [Erwinia tracheiphila]
ATGCCAAACCTCATTCACAGCGATACAACAGCCAGCATCAGTGAGCTGAAGAAAAACCCTATGGCCACTGTCAATGCAGG
CGCCGGCTCTCCCGTGGCTATTCTGAACCATAACCAACCTGCTTTTTACTGTGTGCCAGCTGAACTCTATGAGCAGATGC
TCGAATACATTGACGAGGAAGAGCTTGCTAAACTGGTTACTAAACGCAGCAAACAGGCATTGCATGATGTGGATCTGGAT
AGCTACTTATGA

Structures

Toxin

• AlphaFold DB: G7SEL6