Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1007409..1007910 Replicon chromosome
Accession NZ_CP068708
Organism Streptococcus suis strain ID33329

Toxin (Protein)


Gene name relE Uniprot ID G7SDZ6
Locus tag JM964_RS04890 Protein ID WP_014637925.1
Coordinates 1007409..1007675 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A116L3F7
Locus tag JM964_RS04895 Protein ID WP_024385716.1
Coordinates 1007659..1007910 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM964_RS04870 1002942..1004012 + 1071 WP_202847701.1 tyrosine recombinase XerS -
JM964_RS04875 1004075..1005583 - 1509 WP_202847702.1 phosphomannomutase/phosphoglucomutase -
JM964_RS04880 1005764..1006705 - 942 WP_024413647.1 sensor histidine kinase -
JM964_RS04885 1006702..1007370 - 669 WP_024413648.1 winged helix-turn-helix domain-containing protein -
JM964_RS04890 1007409..1007675 - 267 WP_014637925.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JM964_RS04895 1007659..1007910 - 252 WP_024385716.1 hypothetical protein Antitoxin
JM964_RS04900 1008001..1009971 - 1971 WP_202847703.1 ABC transporter permease -
JM964_RS04905 1009972..1010724 - 753 WP_015646831.1 ABC transporter ATP-binding protein -
JM964_RS04910 1010752..1011123 - 372 WP_202847704.1 NisI/SpaI family lantibiotic immunity lipoprotein -
JM964_RS04915 1011136..1011276 - 141 WP_044683303.1 hypothetical protein -
JM964_RS04920 1011417..1012583 - 1167 WP_202847705.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 966457..1169444 202987


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10345.99 Da        Isoelectric Point: 10.7260

>T187659 WP_014637925.1 NZ_CP068708:c1007675-1007409 [Streptococcus suis]
MKTSYKLVPTGRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T187659 NZ_CP089934:4641325-4641609 [Erwinia tracheiphila]
ATGAAAGAAGAACTTAAAAAATTTGATGTTGTTGAATTTCTTGAAGATGAAGAAGATATTCAGGAATATCTTAATGCTGC
AATTGAAGAAGATGATACAAAATACCTTTTTAAAGCATTAGGTAACATAGCCAGAGCAAGAAACATGAGTCAGCTATCTA
AAGAAGTTGGCATGTCCAGAGAGGGAATTTACAAGGCGTTATCCGGTGAAGGGAATCCATCATTCCAGACTGTTTCTAAA
ATCACAAAAGCGCTAGGCTTAAAACTTCACTTCACAGGGGCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9296.46 Da        Isoelectric Point: 3.6675

>AT187659 WP_024385716.1 NZ_CP068708:c1007910-1007659 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALAEYEADLANGIEPISWEEMLEDLGLTDE
DQL

Download         Length: 252 bp

>AT187659 NZ_CP089934:4641027-4641323 [Erwinia tracheiphila]
ATGATCGAGATAAAACGGACGCCGGAAGTTGAAAAATGGCTCAAGTCTTTGAAAGACAGAACGGCAAAAGCAAAAATATT
AATGCGACTTGAACGGATGGAGGACGGGAATTTTGGAGATGTAGAGCCTATTGGTGATGGCTTATCTGAATTGAGAGTTC
ATCAGGGTAAAGGCTACCGTGTGTATTTTGGGAACAAAAATAATAAAATTATTCTCTTGCTTTGCGGTGGAGATAAAAGC
ACACAGCAGGCAGATATCAGAAAGGCAAAACAATTAGCCAAACAGTGGGGTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SDZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A116L3F7

References