Detailed information of TA system TA187658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 809169..810412
• Replicon: chromosome
• Accession: NZ_CP068708
• Organism: Streptococcus suis strain ID33329

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: G7SEB4
• Locus tag: JM964_RS03980
• Protein ID: WP_001235242.1
• Coordinates: 809645..810412 (+)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: JM964_RS03975
• Protein ID: WP_000578719.1
• Coordinates: 809169..809645 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JM964_RS03935	804612..805571	+	960	Protein_741	hypothetical protein	-
JM964_RS03940	805642..805941	+	300	WP_014636295.1	hypothetical protein	-
JM964_RS03945	805955..806245	+	291	WP_000893083.1	hypothetical protein	-
JM964_RS03950	806340..806978	+	639	WP_014636296.1	hypothetical protein	-
JM964_RS03955	807018..808118	+	1101	WP_014636297.1	toprim domain-containing protein	-
JM964_RS03960	808146..808373	+	228	WP_000110922.1	hypothetical protein	-
JM964_RS03965	808370..808759	+	390	WP_044475264.1	hypothetical protein	-
JM964_RS03970	808809..809099	+	291	WP_000667951.1	hypothetical protein	-
JM964_RS03975	809169..809645	+	477	WP_000578719.1	helix-turn-helix domain-containing protein	Antitoxin
JM964_RS03980	809645..810412	+	768	WP_001235242.1	zeta toxin family protein	Toxin
JM964_RS03985	810449..812956	+	2508	WP_001213955.1	AAA family ATPase	-
JM964_RS03990	813294..813656	+	363	WP_202847669.1	hypothetical protein	-
JM964_RS03995	813659..814024	+	366	WP_000431640.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B) / tet(O)	-	702726..900219	197493

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 28985.80 Da
• Isoelectric Point: 5.1126

>T187658 WP_001235242.1 NZ_CP068708:809645-810412 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK

Nucleotide

• Length: 768 bp

>T187658 NZ_CP089934:4641027-4641323 [Erwinia tracheiphila]
ATGATCGAGATAAAACGGACGCCGGAAGTTGAAAAATGGCTCAAGTCTTTGAAAGACAGAACGGCAAAAGCAAAAATATT
AATGCGACTTGAACGGATGGAGGACGGGAATTTTGGAGATGTAGAGCCTATTGGTGATGGCTTATCTGAATTGAGAGTTC
ATCAGGGTAAAGGCTACCGTGTGTATTTTGGGAACAAAAATAATAAAATTATTCTCTTGCTTTGCGGTGGAGATAAAAGC
ACACAGCAGGCAGATATCAGAAAGGCAAAACAATTAGCCAAACAGTGGGGTTTTTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18266.77 Da
• Isoelectric Point: 4.6424

>AT187658 WP_000578719.1 NZ_CP068708:809169-809645 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT187658 NZ_CP089934:4641325-4641609 [Erwinia tracheiphila]
ATGAAAGAAGAACTTAAAAAATTTGATGTTGTTGAATTTCTTGAAGATGAAGAAGATATTCAGGAATATCTTAATGCTGC
AATTGAAGAAGATGATACAAAATACCTTTTTAAAGCATTAGGTAACATAGCCAGAGCAAGAAACATGAGTCAGCTATCTA
AAGAAGTTGGCATGTCCAGAGAGGGAATTTACAAGGCGTTATCCGGTGAAGGGAATCCATCATTCCAGACTGTTTCTAAA
ATCACAAAAGCGCTAGGCTTAAAACTTCACTTCACAGGGGCGTAA

Structures

Toxin

• AlphaFold DB: G7SEB4