Detailed information of TA system TA187656

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 491333..491981
• Replicon: chromosome
• Accession: NZ_CP068708
• Organism: Streptococcus suis strain ID33329

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JM964_RS02475
• Protein ID: WP_044679833.1
• Coordinates: 491333..491494 (+)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G7SGM2
• Locus tag: JM964_RS02480
• Protein ID: WP_014637654.1
• Coordinates: 491532..491981 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JM964_RS02455	488005..488472	+	468	WP_014637647.1	SsrA-binding protein SmpB	-
JM964_RS02460	488875..489558	+	684	WP_044679832.1	hypothetical protein	-
JM964_RS02465	489560..490417	+	858	WP_052502457.1	ABC transporter ATP-binding protein	-
JM964_RS02470	490716..490946	+	231	WP_044681195.1	hypothetical protein	-
JM964_RS02475	491333..491494	+	162	WP_044679833.1	type II toxin-antitoxin system HicA family toxin	Toxin
JM964_RS02480	491532..491981	+	450	WP_014637654.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JM964_RS02485	492142..493185	-	1044	WP_202847719.1	alcohol dehydrogenase catalytic domain-containing protein	-
JM964_RS02490	493339..494199	+	861	WP_044762617.1	SAM-dependent methyltransferase TehB	-
JM964_RS02495	494392..496323	+	1932	WP_202847630.1	C69 family dipeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-52)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 5807.85 Da
• Isoelectric Point: 10.9132

>T187656 WP_044679833.1 NZ_CP068708:491333-491494 [Streptococcus suis]
MVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 162 bp

>T187656 NZ_CP089934:3447782-3448000 [Erwinia tracheiphila]
ATGACAAACAAAGTTCTTACTAAAACTGATTATCTTATGCGTTTAAGAAAGTGTCGTTCTATCGACACCCTGGAACGCGT
TATAGAAAAGAACAAATACGAATTATCCGACAATGAGCTGGCAGTATTTTATTCTGCTGCTGACCATCGCCTGGCTGAAC
TCACTATGAATAAGCTTTACGATAAGGTGCCTGTTTCAGTCTGGAAATTCATACGTTAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16664.69 Da
• Isoelectric Point: 3.9458

>AT187656 WP_014637654.1 NZ_CP068708:491532-491981 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEYSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 450 bp

>AT187656 NZ_CP089934:3447376-3447756 [Erwinia tracheiphila]
ATGGACGAGTATTCACCAAAAAGGCATGATGTTGCACAATTAAAATTCTTGTGTGAAAATTTGTACGATGAAAGCATGAC
AACAATAGGTGACAGCCATCATGGATGGATTAACGATCCGACTTCTGCCAGCAATTTACAGCTTAACGATTTGATTGAGC
ACATAGCCTCATTTACCATGAATTACAAAATTAAACATATTGAAGATAGCGATCTGATTAGTCAGATTGATGAATATCTT
GATGACACTTTTATGCTCTTTAGTAATTACGGCATTAATGTTCAGGAACTGCAACGCTGGCGAAAATCAGCTGAAGGGTT
GTTTAGCATTTTTGCAGAGGAGTGCGCTCAAGTTGCCAATCCTGCGAGCCACTCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: G7SGM2