Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-YafN |
Location | 104498..105020 | Replicon | plasmid p1-pV-hybrid-1 |
Accession | NZ_CP068707 | ||
Organism | Escherichia coli strain J53-p1-pV-hybrid-1 |
Toxin (Protein)
Gene name | stbE | Uniprot ID | A0A2J4R0S6 |
Locus tag | JK375_RS23150 | Protein ID | WP_004181778.1 |
Coordinates | 104498..104782 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | A0A2J4R0U8 |
Locus tag | JK375_RS23155 | Protein ID | WP_004181777.1 |
Coordinates | 104772..105020 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JK375_RS23120 | 99699..100794 | + | 1096 | Protein_104 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
JK375_RS23125 | 100893..102080 | - | 1188 | WP_131860749.1 | transposase | - |
JK375_RS23130 | 102116..102544 | + | 429 | WP_077257669.1 | IS200/IS605 family transposase | - |
JK375_RS23135 | 102623..102847 | + | 225 | Protein_107 | transposase | - |
JK375_RS23140 | 103118..104344 | - | 1227 | WP_040209639.1 | transposase | - |
JK375_RS23145 | 104380..104481 | + | 102 | Protein_109 | IS200/IS605 family transposase | - |
JK375_RS23150 | 104498..104782 | - | 285 | WP_004181778.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JK375_RS23155 | 104772..105020 | - | 249 | WP_004181777.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
JK375_RS23160 | 105311..107110 | + | 1800 | WP_004181776.1 | ATP-dependent helicase | - |
JK375_RS23165 | 107444..108430 | + | 987 | WP_025368599.1 | hypothetical protein | - |
JK375_RS23170 | 108575..108928 | + | 354 | WP_004181774.1 | hypothetical protein | - |
JK375_RS23175 | 108990..109811 | + | 822 | WP_004181772.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | aph(7'')-Ia | rmpA / iutA / iucD / iucC / iucB / iucA / iroN / iroD / iroC / iroB | 1..324396 | 324396 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10970.69 Da Isoelectric Point: 10.6516
>T187651 WP_004181778.1 NZ_CP068707:c104782-104498 [Escherichia coli]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN
Download Length: 285 bp
>T187651 NZ_CP089934:1130459-1130860 [Erwinia tracheiphila]
GTGGCCCTGTGGCACTCTGAGCTGCGGGTCTCATGGCGAGCACAGTGGTTTTCATTGCTGCTGCACGGCGTGGCGATCCT
GATTGTGCTGCTGGCACCCTGGCCGGCCAGCTATACGGTGGTGTGGATGTCACTCCTCACGCTAACGATATTTGAGTGCG
TGCGGAGCCAGCGGAGAATAGGCAACCGTGAGGGAGAAATTGCCCTGTTTGAGGGGCGGCAGGTGCAATGGCGGCAGAAG
CGCTGGCAGATTCGCGGGCGACCCTGGATTACCCGACAGGCTATTTTAATGACGCTGCGTTCAGCAACCGGAGAACGCGA
AAAGCTTTGGTTATTTTCAGACAGTATGTCCGCGGAAGACTGGCGATCGCTTCGAAAGCAATTACTTCGGGCGGCTCTAT
AG
GTGGCCCTGTGGCACTCTGAGCTGCGGGTCTCATGGCGAGCACAGTGGTTTTCATTGCTGCTGCACGGCGTGGCGATCCT
GATTGTGCTGCTGGCACCCTGGCCGGCCAGCTATACGGTGGTGTGGATGTCACTCCTCACGCTAACGATATTTGAGTGCG
TGCGGAGCCAGCGGAGAATAGGCAACCGTGAGGGAGAAATTGCCCTGTTTGAGGGGCGGCAGGTGCAATGGCGGCAGAAG
CGCTGGCAGATTCGCGGGCGACCCTGGATTACCCGACAGGCTATTTTAATGACGCTGCGTTCAGCAACCGGAGAACGCGA
AAAGCTTTGGTTATTTTCAGACAGTATGTCCGCGGAAGACTGGCGATCGCTTCGAAAGCAATTACTTCGGGCGGCTCTAT
AG
Antitoxin
Download Length: 83 a.a. Molecular weight: 8925.17 Da Isoelectric Point: 3.8209
>AT187651 WP_004181777.1 NZ_CP068707:c105020-104772 [Escherichia coli]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL
Download Length: 249 bp
>AT187651 NZ_CP089934:1130212-1130478 [Erwinia tracheiphila]
ATGGATATAAGTAATAAAGCCCGTGTTCACTGGGCCTGCCGTCGTGGCATGCGTGAACTGGATATCTCTATTATGCCGTT
TTTTGAATATGAGTACGATTCACTGAGCGACAGTGACAAACTGGTTTTTGTACGCCTGTTGGAAAATGACGATCCCGATC
TTTTTAACTGGCTGATGAATTACGGCGAGCCGCCAGACACCGAGCTGAAACGTATGGTGCTTCTCATTCAGCAGCGAAAC
AAGCAACGTGGCCCTGTGGCACTCTGA
ATGGATATAAGTAATAAAGCCCGTGTTCACTGGGCCTGCCGTCGTGGCATGCGTGAACTGGATATCTCTATTATGCCGTT
TTTTGAATATGAGTACGATTCACTGAGCGACAGTGACAAACTGGTTTTTGTACGCCTGTTGGAAAATGACGATCCCGATC
TTTTTAACTGGCTGATGAATTACGGCGAGCCGCCAGACACCGAGCTGAAACGTATGGTGCTTCTCATTCAGCAGCGAAAC
AAGCAACGTGGCCCTGTGGCACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4R0S6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4R0U8 |