187649

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4158314..4158909 Replicon chromosome
Accession NZ_CP068706
Organism Escherichia coli strain J53-p1-pV-hybrid-1

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag JK375_RS20175 Protein ID WP_000239577.1
Coordinates 4158314..4158664 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag JK375_RS20180 Protein ID WP_001223208.1
Coordinates 4158658..4158909 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK375_RS20155 4153760..4154782 - 1023 WP_001313531.1 ABC transporter permease -
JK375_RS20160 4154796..4156298 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
JK375_RS20165 4156438..4157394 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JK375_RS20170 4157704..4158234 + 531 WP_000055075.1 inorganic diphosphatase -
JK375_RS20175 4158314..4158664 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
JK375_RS20180 4158658..4158909 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JK375_RS20185 4159121..4159462 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JK375_RS20190 4159465..4163244 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T187649 WP_000239577.1 NZ_CP068706:c4158664-4158314 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T187649 NZ_CP089934:314369-314752 [Erwinia tracheiphila]
ATGAAATGGATTAGCGCTCAGGAGGTGATAGCGTTTCATGACCGTCTGCTTACAGCTTTGCCGGGCGTTCAGGGAATGCC
AGAGCCGGGAAGAGCAGAGGCGATCATTTATCGTGTTCAGAACCAGCTTTACTATGAAGGTGTTGAGGATATTCACGAAC
TGGCTGCAATGTATCTTGTCGCTATTTCGCGTGGTCATATCTTCAATGACGGCAATAAGCGAACCGCCTTTTTCGTTGCG
ATGGCTTTTTTAAAGCGCAATGGCATTGATATCCGTGACGAAGGTGATGAACTGGAAGAACTGACGGTATCCGCAGCGAT
GGGGGCAGTAAGCAGCGATGATATTGCTGCTGTTTTGCGCCGATTATCCATCAATCCCCACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT187649 WP_001223208.1 NZ_CP068706:c4158909-4158658 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT187649 NZ_CP089934:314151-314372 [Erwinia tracheiphila]
ATGCGAACCTATACCACATCTCAGGCCCGGCAAAATATTGCCGAAGTAATGGAAGCGGCTACGGCTGGTGAGCCTGTAGA
AATAACTCGCCGCGATGGCTCTGCCGCTGTGCTTATCAGCCGAGATGATTTCAACGCGTGGCAGGAAGCAAAGCTGGATG
CTGAATTTGCCGAAATTATGGGGCGACACGGTCGTACCATTAAGGCGCTGGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References