Detailed information of TA system TA187648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3929113..3929927
• Replicon: chromosome
• Accession: NZ_CP068706
• Organism: Escherichia coli strain J53-p1-pV-hybrid-1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: JK375_RS19145
• Protein ID: WP_001054376.1
• Coordinates: 3929113..3929370 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: JK375_RS19150
• Protein ID: WP_001309181.1
• Coordinates: 3929382..3929927 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK375_RS19125	3924401..3925507	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
JK375_RS19130	3925572..3926552	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
JK375_RS19135	3927135..3928375	-	1241	Protein_3740	DNA helicase	-
JK375_RS19140	3928491..3928736	+	246	Protein_3741	GNAT family N-acetyltransferase	-
JK375_RS19145	3929113..3929370	+	258	WP_001054376.1	hypothetical protein	Toxin
JK375_RS19150	3929382..3929927	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
JK375_RS19155	3929983..3930729	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
JK375_RS19160	3930898..3931116	+	219	Protein_3745	hypothetical protein	-
JK375_RS19165	3931154..3931270	+	117	Protein_3746	VOC family protein	-
JK375_RS19170	3931515..3932636	+	1122	WP_000010829.1	M42 family metallopeptidase	-
JK375_RS19175	3932633..3932911	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JK375_RS19180	3932923..3934236	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T187648 WP_001054376.1 NZ_CP068706:3929113-3929370 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T187648 NZ_CP089934:312508-312783 [Erwinia tracheiphila]
ATGAATCAAGCCGTTAAAAATCTCAGGAAAAAGCAGCGTGATACCCTGGAACAGATATTCAGAACGTCGCCACCGTCAGG
ACTGAAGTGGTCAGCGGTGGAGTCCCTGATCGGCGCTCTGTGCGGCAAAATTAAAGAGGGTAGCGGATCGCGCGTGCGTT
TTTTGCTTAACGGCAGTATTGCCCGTTTCCACCGTCCGCACCCGTCACCTGATACCGATAAAGGCGCAGTCGTCAGCCTG
CGCGAATGGTTAGAAAGCACCGGAGTGAAACCATGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT187648 WP_001309181.1 NZ_CP068706:3929382-3929927 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT187648 NZ_CP089934:312780-313139 [Erwinia tracheiphila]
ATGACAAAACCAGCCACCCCAAATATGATCGTTATTGCCGGGCAGCCAGCGGTTGTCAGCTACGTGCCGGAAATTAATAT
GTTTCGCGGGCGCTTTCTGGGGCTGACAGGCTACTGTGACTTTGTTTCTGACAGTATTCAGGGACTGAACAAAGAAGGCG
ATATTTCGCTTCGTGAGTATCTGGAAGATTGTAGTGCGGAAGGTATAGAACCTTACGCCCGCCAGGAAAAAACCAGGACA
TTCACGCTTCGCTACCCTGAATCTTTCGGCGAACGCCTGAATCAGGCAGCCGCAGAAAATGAAGTATCGGTGAATGCGTT
CATTGTTGAGACGTTAAACGAGCGCATGAAGCATGCCTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8